CAS No. 22916-47-8
| IUPAC Name | 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole | |
|---|---|---|
| CAS Number | 22916-47-8 | |
| Molecular Formula |
C18H14Cl4N2O |
|
| Molecular Weight (MW) | 416.13 | |
| SMILES | C1=CC(=C(C=C1Cl)Cl)COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl | |
| InChIKey | BYBLEWFAAKGYCD-UHFFFAOYSA-N |
Miconazole is an imidazole antifungal agent that inhibits lanosterol 14α-demethylase, a key enzyme involved in fungal ergosterol biosynthesis. Disruption of ergosterol production by miconazole impairs fungal cell membrane integrity and function, leading to altered membrane permeability and the inhibition of fungal growth. Beyond its primary antifungal activity, miconazole also demonstrates antiparasitic activity against certain Leishmania species and possesses limited antibacterial properties. [1]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
83 mg/mL
(199.45 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 83 mg/mL |
| Water | Insoluble |
| DMSO |
83 mg/mL
(199.45 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 83 mg/mL |
| Water | Insoluble |
| DMSO |
83 mg/mL
(199.45 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
| DMSO |
83 mg/mL
(199.45 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
| DMSO |
83 mg/mL
(199.45 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 83 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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