CAS No. 17560-51-9
Batch:
Purity:99.93
Chemical Structure
Check the
Metolazone
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 17560-51-9 | |
|---|---|---|
| Molecular Formula |
C16H16ClN3O3S |
|
| Molecular Weight (MW) | 365.83 | |
| SMILES | CC1NC2=CC(=C(C=C2C(=O)N1C3=CC=CC=C3C)S(=O)(=O)N)Cl |
Metolazone is a thiazide-like diuretic that acts as an inhibitor of the sodium-chloride symporter (NCC) in renal tubular cells. By blocking the function of the sodium-chloride symporter, metolazone prevents the reabsorption of sodium, chloride, and water from the tubular lumen into tubule epithelial cells. This pathway blockade increases urine volume and promotes renal excretion of electrolytes, thereby decreasing total blood volume.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
73 mg/mL
(199.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 15 mg/mL |
| Water | Insoluble |
| DMSO |
73 mg/mL
(199.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 8 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.