CAS No. 79794-75-5
| IUPAC Name | ethyl 4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate | |
|---|---|---|
| CAS Number | 79794-75-5 | |
| Molecular Formula |
C22H23ClN2O2 |
|
| Molecular Weight (MW) | 382.88 | |
| SMILES | CCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1 | |
| InChIKey | JCCNYMKQOSZNPW-UHFFFAOYSA-N |
Loratadine is a selective histamine H1 receptor antagonist and inverse agonist that targets peripheral H1 receptors to block histamine-mediated signaling. By suppressing histamine H1 receptor activity, loratadine inhibits downstream inflammatory pathways, reducing capillary permeability, vasodilation, and allergic responses. Additionally, it functions as a selective inhibitor of the solute carrier transporter B(0)AT2, thereby modulating amino acid transport mechanisms. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| Ethanol | 77 mg/mL |
| DMSO |
17 mg/mL
(44.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | 77 mg/mL |
| DMSO |
17 mg/mL
(44.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| DMSO |
76 mg/mL
(198.49 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 76 mg/mL |
| Water | Insoluble |
| DMSO |
77 mg/mL
(201.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 77 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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