CAS No. 192725-17-0
Batch:
Purity:99.94
Chemical Structure
Check the
Lopinavir (ABT-378)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2S)-N-[(2S,4S,5S)-5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide | |
|---|---|---|
| CAS Number | 192725-17-0 | |
| Molecular Formula |
C37H48N4O5 |
|
| Molecular Weight (MW) | 628.8 | |
| SMILES | CC1=C(C(=CC=C1)C)OCC(=O)NC(CC2=CC=CC=C2)C(CC(CC3=CC=CC=C3)NC(=O)C(C(C)C)N4CCCNC4=O)O | |
| InChIKey | KJHKTHWMRKYKJE-SUGCFTRWSA-N |
Lopinavir (ABT-378) is a highly potent HIV-1 protease inhibitor with a Ki of. By selectively binding to and inhibiting the catalytic site of HIV-1 protease, lopinavir blocks the cleavage of viral Gag and Gag-Pol polyprotein precursors. This inhibition disrupts mature viral protein processing, preventing viral maturation and resulting in the release of immature, noninfectious virions. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
126 mg/mL
(200.38 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 126 mg/mL |
| Water | Insoluble |
| DMSO |
126 mg/mL
(200.38 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 126 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Lopinavir (ABT-378) Clinical Trials
- Lopinavir (ABT-378) Solubility in DMSO
- Lopinavir (ABT-378) Stock Solution
- Lopinavir (ABT-378) Storage
- Lopinavir (ABT-378) Stability
- Lopinavir (ABT-378) Molecular Weight
- Lopinavir (ABT-378) SMILES
- Lopinavir (ABT-378) Chemical Structure (2D and 3D)
- Lopinavir (ABT-378) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.