CAS No. 165800-03-3

Batch: Purity:99.99
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Linezolid (PNU-100766) Chemical Structure
Chemical Structure
Check the Linezolid (PNU-100766) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[[(5S)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide
CAS Number 165800-03-3
Molecular Formula

C16H20FN3O4
Molecular Weight (MW) 337.35
SMILES CC(=O)NCC1CN(C(=O)O1)C2=CC(=C(C=C2)N3CCOCC3)F
InChIKey TYZROVQLWOKYKF-ZDUSSCGKSA-N

Ordering Information

Biological Activity

Linezolid (PNU-100766) is a synthetic oxazolidinone antibacterial agent targeting the bacterial 50S ribosomal subunit. By binding to the 23S ribosomal RNA within the 50S subunit, linezolid inhibits the formation of the 70S initiation complex required for protein translation. This targeted mechanism suppresses bacterial protein synthesis and halts the proliferation of multidrug-resistant Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 68 mg/mL (201.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 10 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.