CAS No. 1229236-86-5
Batch:
Purity:99.95
Chemical Structure
Check the
Gandotinib (LY2784544)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-[(4-chloro-2-fluorophenyl)methyl]-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholin-4-ylmethyl)imidazo[1,2-b]pyridazin-6-amine | |
|---|---|---|
| CAS Number | 1229236-86-5 | |
| Molecular Formula |
C23H25ClFN7O |
|
| Molecular Weight (MW) | 469.94 | |
| SMILES | CC1=CC(=NN1)NC2=NN3C(=C(N=C3C(=C2)CN4CCOCC4)C)CC5=C(C=C(C=C5)Cl)F | |
| InChIKey | SQSZANZGUXWJEA-UHFFFAOYSA-N |
Gandotinib (LY2784544) is a potent, small-molecule kinase inhibitor targeting Janus kinase 2 (JAK2), with selective activity against the mutant JAK2 V617F enzyme. By selectively suppressing JAK2 kinase activity, it blocks downstream STAT5 phosphorylation and interrupts the JAK/STAT signaling pathway. This inhibition impairs mutant JAK2-driven cellular proliferation and induces apoptosis in myeloproliferative disease models.
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
94 mg/mL
(200.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 9 mg/mL |
| Water | Insoluble |
| DMSO |
94 mg/mL
(200.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 94 mg/mL |
| Water | Insoluble |
| DMSO |
94 mg/mL
(200.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 9 mg/mL |
| Water | Insoluble |
| DMSO |
94 mg/mL
(200.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 12 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Gandotinib (LY2784544) Clinical Trials
- Gandotinib (LY2784544) Solubility in DMSO
- Gandotinib (LY2784544) Stock Solution
- Gandotinib (LY2784544) Storage
- Gandotinib (LY2784544) Stability
- Gandotinib (LY2784544) Molecular Weight
- Gandotinib (LY2784544) SMILES
- Gandotinib (LY2784544) Chemical Structure (2D and 3D)
- Gandotinib (LY2784544) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.