Clinical Trials

Numerous clinical trials evaluate ketorolac across diverse indications, including acute and postoperative pain, renal colic, knee osteoarthritis, cataracts, and pancreatic ductal adenocarcinoma. Spanning Early Phase 1 through Phase 4, these studies encompass recruiting, active, completed, and terminated statuses sponsored by academic institutions, health systems, and medical investigators. Representative research explores applications such as intravenous dosing for acute emergency pain and cachexia management in advanced pancreatic cancer.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07158476 RECRUITING
ACL Surgery; Pain Management
St. Louis University
 2025-10-21 PHASE4
NCT06994442 RECRUITING
Mechanical Ventilation; Pediatric Acute Respiratory Failure; Analgesics, Opioid; Sedation and Analgesia
Weill Medical College of Cornell University
 2025-12-29 PHASE3
NCT06160778 RECRUITING
Acute Pain; Abdomen, Acute; Abdominal Pain; Appendicitis; Emergencies; Child, Only
University of Calgary
 2024-05-27 PHASE3
NCT07743606 ENROLLING_BY_INVITATION
NSAID (Non-Steroidal Anti-Inflammatory Drug); Lumbar Spine Fusion; Ketorolac; Postoperative Pain
Rothman Institute Orthopaedics
 2024-07-08 PHASE3
NCT07430085 NOT_YET_RECRUITING
Periarticular Block; Osteoarthritis (OA); Osteoarthritis (OA) of the Knee; Pain After Surgery; Knee Arthroplasty, Total
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
 2026-07-31 PHASE4
NCT07047040 NOT_YET_RECRUITING
Pain, Postoperative; Osteoarthritis, Knee
Assiut University
 2025-08-15 PHASE2; PHASE3
NCT07185724 RECRUITING
Infertility (IVF Patients); Infertility Treatment; Post-op Pain; Fresh Embryo Transfer; Oocyte Retrieval and Post Operative Pain Control
Jessica D. Kresowik
 2025-11-08 PHASE4
NCT04040452 RECRUITING
Congenital Heart Disease in Children
Phoenix Children's Hospital
 2021-03-01 PHASE4
NCT07092566 RECRUITING
Renal Carcinoma; Nephrectomy / Methods; Pain Management
Wake Forest University Health Sciences
 2025-11-14 PHASE3
NCT06968806 RECRUITING
Aortic Dissection; Inflammation
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
 2025-10-27 PHASE3
NCT07753629 NOT_YET_RECRUITING
Wide Excision; Postoperative Pain
Seoul National University Hospital
 2026-08-07
NCT06579703 NOT_YET_RECRUITING
Sickle Cell Disease; Sickle Cell Crisis; Veno-occlusive Disease
Children's Blood and Cancer Center at Dell Children's Medical Center
 2024-09-30 PHASE4
NCT05292339 RECRUITING
Osteoarthritis; Tendinopathy; Arthropathy
Emory University
 2023-01-31 PHASE4
NCT06513208 RECRUITING
Lumbar Spinal Fusion
University of Maryland St. Joseph Medical Center
 2026-01 PHASE4
NCT05543785 RECRUITING
Postoperative Pain, Acute
Mansoura University
 2022-11-01
NCT07487246 RECRUITING
Pain Management; Abortion; Second Trimester Abortion; Dilation and Evacuation
Rush University Medical Center
 2026-06-29 PHASE2
NCT06150898 RECRUITING
Early-stage Breast Cancer; Estrogen-receptor-positive Breast Cancer
Jules Bordet Institute
 2025-05-12 PHASE2
NCT06158620 RECRUITING
Post Operative Pain; Urolithiasis; Ureter Calculi; Stent Complication
University of Texas Southwestern Medical Center
 2025-03-01 PHASE1; PHASE2
NCT07368738 ENROLLING_BY_INVITATION
Extracorporeal Shockwave Lithotripsy
Horizon Health Network
 2026-04 PHASE4
NCT04771156 RECRUITING
Cleft Lip and Palate
The University of Texas Health Science Center, Houston
 2021-09-17 PHASE4
NCT07773155 RECRUITING
Surgery, Upper Extremity
University of Chicago
 2025-03-17 PHASE4
NCT06447194 WITHDRAWN
Degenerative Lumbar Spinal Stenosis; Degenerative Disc Disease; Degenerative Spondylolisthesis; Degenerative Disease
University of Maryland, Baltimore
 2025-10-01 PHASE1; PHASE2
NCT05992883 RECRUITING
Thumb Osteoarthritis
Mayo Clinic
 2023-07-28 PHASE3
NCT06201676 RECRUITING
Orthopaedic Trauma; Chronic Opioid Use
Massachusetts General Hospital
 2025-02-28 PHASE4
NCT03823534 RECRUITING
Bone Metastases; Lymphoma; Multiple Myeloma; Opioid Use; Pain
St. Louis University
 2019-02-20 PHASE3
NCT07006168 RECRUITING
Patella Fracture
The University of Hong Kong
 2024-11-01 PHASE4
NCT06819956 RECRUITING
Pain Management
University of Alberta
 2025-06-23 PHASE3
NCT03513770 RECRUITING
Venous Distension Reflex; Blood Pressure
Milton S. Hershey Medical Center
 2019-08-14 EARLY_PHASE1
NCT04895280 WITHDRAWN
Full-thickness Rotator Cuff Tear; Rotator Cuff Tendinitis
Michael Khazzam
 2024-11 PHASE4
NCT07705763 NOT_YET_RECRUITING
Refraction Error; Photorefractive Keratectomy
Madina Teaching Hospital Faisalabad
 2026-08-01
NCT05575999 NOT_YET_RECRUITING
Pain Management
Kansas City Heart Rhythm Research Foundation
 2026-01 PHASE1
NCT03638999 RECRUITING
Ureteral Stent Placement; Kidney Stone
Washington University School of Medicine
 2018-07-31 EARLY_PHASE1
NCT05842044 RECRUITING
Kidney Cancer; Renal Cancer; Renal Neoplasm
University of Miami
 2023-09-15 PHASE2
NCT06653400 RECRUITING
Abnormal Uterine Bleeding; Analgesia; Paracervical Block
Icahn School of Medicine at Mount Sinai
 2025-02-27 PHASE1
NCT07037888 RECRUITING
Femoracetabular Impingement; Hip Arthroscopy
Henry Ford Health System
 2023-12-13 PHASE4
NCT04130464 RECRUITING
Hysterectomy; Gynecologic Surgical Procedures; Narcotic Use; Pain, Postoperative
Ying Liu
 2019-09-30 PHASE4
NCT05776953 COMPLETED
Renal Colic; Flank Pain; Emergencies; Analgesia
Hackensack Meridian Health
 2023-12-21 PHASE4
NCT07102641 ACTIVE_NOT_RECRUITING
Cesarean Delivery; Postpartum Comfort; Postpartum Pain; Post-operative Pain; NSAIDs; Acetaminophen (D000082)
Thomas Jefferson University
 2025-08-26 PHASE4
NCT06853327 ENROLLING_BY_INVITATION
IUD Insertion Pain
University of North Carolina, Chapel Hill
 2025-05-23 PHASE2
NCT07305883 NOT_YET_RECRUITING
Pain; Digital Block
Tehran University of Medical Sciences
 2025-12-28 PHASE3
NCT03978767 COMPLETED
Preeclampsia Severe; Preeclampsia Postpartum
Washington University School of Medicine
 2019-06-10 PHASE2
NCT06973785 ACTIVE_NOT_RECRUITING
ACL - Anterior Cruciate Ligament Rupture; ACL Injuries
The Cleveland Clinic
 2025-07-15 PHASE2
NCT07276906 NOT_YET_RECRUITING
Postoperative Pain
University of South Alabama
 2026-01 PHASE4
NCT06081101 NOT_YET_RECRUITING
Sacro-iliac Joint Pain
McMaster University
 2025-01 EARLY_PHASE1
NCT06519955 RECRUITING
Hip Dysplasia
Michael C Willey
 2024-10-03 PHASE2; PHASE3
NCT07244757 COMPLETED
Postoperative Analgesia; Cesarean Delivery; Ketorolac
Cairo University
 2025-12-01
NCT04505566 COMPLETED
Diabetic Retinopathy
Stephen J. Kim, MD
 2020-11-09 PHASE1
NCT06584188 NOT_YET_RECRUITING
Postoperative Pain
Ain Shams University
 2026-04-11 PHASE2
NCT07064083 COMPLETED
To Evaluate the Effectiveness of Intra-canal Nano-ketrolac as a Medicament in Reducing Post-endodontic Pain in Patients Undergoing Root Canal Treatment
Al-Azhar University
 2025-08-01 EARLY_PHASE1
NCT05597878 TERMINATED
Pain Management; Opioid Use; Prostate Cancer
Wake Forest University Health Sciences
 2023-04-18 PHASE2; PHASE3
NCT07352059 NOT_YET_RECRUITING
Sedation and Analgesia Management in Patients Undergoing Flexible Bronchoscopy
SYED HAIDER ALI
 2026-01-20
NCT07744503 COMPLETED
Pain, Postoperative; Osteoarthritis, Knee; Arthroplasty, Replacement, Knee
Christopher Male
 2025-06-01
NCT06326983 COMPLETED
Tonsillitis; Post-operative Nausea and Vomiting (PONV); Emergence Delirium; Opioid Analgesic Adverse Reaction; Anesthesia; Pain
Boston Children's Hospital
 2024-05-09
NCT06083571 TERMINATED
Headache, Migraine
Washington University School of Medicine
 2024-01-01 PHASE2
NCT07257874 COMPLETED
Mastectomy, Modified Radical
Islamabad Medical and Dental College
 2025-07-01 PHASE3
NCT02465138 WITHDRAWN
Pancreatitis
University of California, San Francisco
 2023-11 PHASE4
NCT05336968 UNKNOWN
Osteoarthritis, Knee
United Health Services Hospitals, Inc.
 2022-09-15 PHASE4
NCT07141589 RECRUITING
Fentanyl; Ketorolac; Adjuvant; Peribulbar Block; Anterior Segment Surgeries
Cairo University
 2024-08-25
NCT06112548 COMPLETED
Arthritis Knee; Pain; Arthroplasty Complications
Damascus University
 2024-03-01
NCT06729047 NOT_YET_RECRUITING
Post-Dural Puncture Headache
Assiut University
 2024-12-15 PHASE1; PHASE2
NCT06539637 UNKNOWN
Cataract
DHS Consulting
 2023-09-01 EARLY_PHASE1
NCT04291599 TERMINATED
Acute Pancreatitis
Boston Children's Hospital
 2022-03-15 PHASE2
NCT06498440 UNKNOWN
Open Angle Glaucoma; Ocular Hypertension; Postoperative Inflammation
St. Joseph's Healthcare Hamilton
 2024-09-01 PHASE4
NCT07183436 COMPLETED
Adhesive Capsulitis of the Shoulder
Mahidol University
 2023-11-01 PHASE3
NCT06484192 UNKNOWN
Spine Fusion; NSAID (Non-Steroidal Anti-Inflammatory Drug); Postoperative Pain
Rothman Institute Orthopaedics
 2024-06-28 PHASE4
NCT06182098 UNKNOWN
Migraine; Migraine in Children
Dayton Children's Hospital
 2023-06-27
NCT06681688 RECRUITING
Cataract
Inder Paul Singh, M.D.
 2024-07-10 PHASE1; PHASE2
NCT05875571 UNKNOWN
IUD; Healthy Female; Contraception; IUD Insertion Complication
Arkansas Children's Hospital Research Institute
 2024-02-05 PHASE4
NCT05641363 COMPLETED
Acute Pain; Abdominal Pain; Migraine; Appendicitis Acute; Renal Colic; Biliary Colic
Hamilton Health Sciences Corporation
 2023-06-01 PHASE3
NCT06395428 RECRUITING
Back Pain; Chronic Pain
Western Michigan University School of Medicine
 2024-07-09 PHASE4
NCT05336266 ACTIVE_NOT_RECRUITING
Pancreas Cancer; Pancreatic Ductal Adenocarcinoma; Pancreatic Cancer
Andrew Hendifar, MD
 2022-07-01 EARLY_PHASE1
NCT05664074 COMPLETED
Post-ERCP Acute Pancreatitis
David Vitale MD
 2022-11-07 PHASE4
NCT04666701 WITHDRAWN
Acute Pain
EMS
 2023-02 PHASE2
NCT05924165 COMPLETED
Nephrolithiasis
Icahn School of Medicine at Mount Sinai
 2023-05-19 PHASE4
NCT03535116 UNKNOWN
Hematoma Postoperative
Dr. Chandran Medical Prof Corp
 2020-01-01 PHASE4
NCT05074056 COMPLETED
Adenotonsillar Hypertrophy; Obstructive Sleep Apnea; Sleep-Disordered Breathing; Acute Post Operative Pain
St. Louis University
 2022-02-08 PHASE4
NCT05488847 ACTIVE_NOT_RECRUITING
Shoulder Arthropathy; Shoulder Pain
Henry Ford Health System
 2022-06-25 PHASE4
NCT06273813 UNKNOWN
Acute Gouty Arthritis; Acute Pain; Gout Flare
Novilla Pharmaceuticals
 2024-02 PHASE1
NCT05908851 UNKNOWN
Shoulder Arthritis; Anesthesia, Local; Local Infiltration
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
 2023-11-01
NCT02681211 UNKNOWN
Migraine Headache
University of Louisville
 2016-02
NCT06307106 COMPLETED
Acute Post Operative Pain
Zagazig University
 2024-01-14
NCT05190341 TERMINATED
Infertility, Female
Madigan Army Medical Center
 2022-03-24 PHASE4
NCT02604537 COMPLETED
DeQuervain Tendinopathy
OrthoCarolina Research Institute, Inc.
 2015-10-15 PHASE4
NCT05324358 SUSPENDED
Pain, Postoperative
Neumentum, Inc.
 2022-12-14 PHASE3
NCT05206110 COMPLETED
Anesthesia; Surgery
Jessa Hospital
 2022-04-21
NCT05062356 COMPLETED
Chronic Postoperative Pain
St. Mary's Research Center, Canada
 2021-11-04 PHASE1
NCT05158699 TERMINATED
Macular Edema; Cystoid Macular Edema; Retinal Disease; Cataract; Lens Diseases; Eye Diseases
Luigi Rondas
 2021-10-13 PHASE3
NCT05975294 UNKNOWN
Multiple Fracture Ribs
Sohag University
 2023-08
NCT05054868 UNKNOWN
Arthrodesis
Medstar Health Research Institute
 2020-04-14 PHASE1
NCT07500454 COMPLETED
Postoperative Pain; Acute Pain
ISSSTE Hospital Regional "Gral. Ignacio Zaragoza"
 2024-06-20
NCT05282251 UNKNOWN
Lung Diseases
Assiut University
 2024-05-17
NCT05861791 COMPLETED
Postoperative Pain, Acute
Chung-Ang University Gwangmyeong Hospital
 2023-02-07
NCT06087237 COMPLETED
Post-Surgical Complication; Breast Cancer Surgery
Mansoura University
 2023-10-30 PHASE2
NCT05983354 UNKNOWN
Acute Migraine Headache
Health Sciences North Research Institute
 2024-01-01
NCT03464461 TERMINATED
Acute Pain
University of Missouri-Columbia
 2018-05-01 PHASE4
NCT05188053 COMPLETED
Total Knee Arthroplasty
Mayo Clinic
 2022-03-11 PHASE4
NCT06167187 UNKNOWN
Anesthesia
Ain Shams University
 2023-06-01
NCT05102591 COMPLETED
Migraine Disorders
University of Calgary
 2022-02-22 PHASE3
NCT04495894 TERMINATED
Non-small Cell Lung Cancer; Renal Cell Carcinoma
Emory University
 2020-08-24 PHASE2
NCT04646967 COMPLETED
Pain, Postoperative; Phimosis; Paraphimosis; Balanitis
Alberta Children's Hospital
 2022-11-25 PHASE2
NCT05756504 UNKNOWN
Acute Pancreatitis
Hayatabad Medical Complex
 2023-02-22 EARLY_PHASE1
NCT03278691 UNKNOWN
Thoracolumbar Spinal Fusions
Henry Ford Health System
 2017-10-03 PHASE4
NCT03825198 UNKNOWN
Pain, Postoperative; Anaesthesia; Surgery; Nerve Block; Anesthesia, Local; Back Pain; Spinal Fusion
Dr M. B. Breebaart
 2019-08-01 PHASE3
NCT04650893 TERMINATED
Dysphagia; Dysphonia
University of Nebraska
 2021-01-02 PHASE3
NCT06267820 COMPLETED
Postoperative Pain, Acute
Sohag University
 2023-06-01 PHASE2
NCT05776953 Recruiting
Renal Colic|Flank Pain|Emergencies|Analgesia
Hackensack Meridian Health
 2023-12-21 Phase 4
NCT06026553 UNKNOWN
Infertility; Infertility, Female; Oocyte Retrieval; Postoperative Pain; Embryo Transfer
Shady Grove Fertility Reproductive Science Center
 2022-08-10 PHASE1
NCT05248984 COMPLETED
Post Cesarean Pain
Ohio State University
 2022-06-08 PHASE4
NCT05782608 COMPLETED
Ibuprofen; Ketorolac; Colorectal Cancer
Cairo University
 2023-04-01
NCT05907993 COMPLETED
Pain, Postoperative
Alexandria University
 2023-02-01 PHASE4
NCT03467750 COMPLETED
Obstructive Sleep Apnea
Emory University
 2018-07-19 PHASE4
NCT04528173 TERMINATED
Anesthesia; Opioid Use; Tonsillitis; Sleep Disorder; Surgery
Children's Hospital of Philadelphia
 2020-07-22 PHASE4
NCT06039423 COMPLETED
Analgesic Efficacy of M-TAPA Block Accomplished Prior to Surgery in Patients Undergoing Laparoscopic Gynecological Surgeries
Alexandria University
 2023-07-02 PHASE2
NCT04829799 WITHDRAWN
Pain Reduction
University of Florida
 2022-02 PHASE4
NCT05194904 UNKNOWN
Postoperative Pain
Assiut University
 2022-01 PHASE2; PHASE3
NCT03671746 COMPLETED
Polytrauma
Arun Aneja
 2019-02-28 PHASE1
NCT06616922 COMPLETED
Conjunctivitis, Bacterial
NTC srl
 2021-11-05 PHASE2
NCT05801900 UNKNOWN
Postoperative Pain; Bariatric Surgery Candidate
Cairo University
 2023-04
NCT05610384 COMPLETED
Postoperative Pain; Hysterectomy
Cairo University
 2022-11-20
NCT05291598 COMPLETED
Total Knee Replacement; Total Hip Replacement
University of Miami
 2022-05-01 PHASE3
NCT04733326 COMPLETED
Post-operative Pain
Cairo University
 2021-09-01 PHASE1
NCT05189704 UNKNOWN
Postoperative Nausea and Vomiting
Seoul National University Hospital
 2021-12-20
NCT04528563 COMPLETED
Abdominal Pain; Appendicitis; Analgesia; Child, Only; Emergencies
Hamilton Health Sciences Corporation
 2021-05-05 PHASE3
NCT04439396 COMPLETED
Breast Reduction; Breast Reconstruction
Carilion Clinic
 2020-06-22 PHASE1
NCT02653742 UNKNOWN
Pain, Postoperative; Otitis Media
Anica Crnkovic
 2015-05 PHASE4
NCT03913702 TERMINATED
Subacromial Impingement; Subacromial Impingement Syndrome
The University of Texas Medical Branch, Galveston
 2019-09-09 PHASE2
NCT03453541 TERMINATED
Analgesic Adverse Reaction
Albany Medical College
 2017-11-21 PHASE4
NCT03119038 WITHDRAWN
Osteoarthritis; Degenerative Joint Disease
Rush University Medical Center
 2016-04-30 PHASE4
NCT04761302 COMPLETED
Femur Fracture; Tibial Fractures
University of Puerto Rico
 2021-04-18 PHASE4
NCT05609955 COMPLETED
Anesthesia; Pain, Postoperative; Surgery; Opioid Use
Indonesia University
 2022-01-01 PHASE4
NCT04939987 WITHDRAWN
Radical Prostatectomies
Wake Forest University Health Sciences
 2022-08 PHASE2; PHASE3
NCT05336968 Recruiting
Osteoarthritis Knee
United Health Services Hospitals Inc.
 2022-09-15 Phase 4
NCT05489796 COMPLETED
Laparoscopic Gynecological Surgery
Seoul National University Bundang Hospital
 2022-06-30
NCT05523102 COMPLETED
Pain, Postoperative
Indonesia University
 2022-03-31 PHASE4
NCT05132595 UNKNOWN
Postoperative Pain; Postoperative Cognitive Dysfunction; Total Knee Arthroplasty
Tianjin Medical University General Hospital
 2021-11-30
NCT05382546 COMPLETED
Healthy Volunteers
Nuance Pharma (shanghai) Co., Ltd
 2022-05-23 PHASE1
NCT05336266 Recruiting
Pancreas Cancer|Pancreatic Ductal Adenocarcinoma|Pancreatic Cancer
Andrew Hendifar MD|Yinuoke Ltd.|Cedars-Sinai Medical Center
 2022-07-01 Early Phase 1
NCT04483427 UNKNOWN
Obstructive Sleep Apnea
Bahaa Mohammed Refaie
 2020-09-20
NCT04141319 UNKNOWN
Pain; Supratentorial Brain Tumor
Beijing Tiantan Hospital
 2021-12 PHASE4
NCT05234619 UNKNOWN
Hand Injuries With Intravenous Regional Anesthesia
Sohag University
 2022-01-01
NCT04353505 WITHDRAWN
Chronic Migraine; Cluster Headache; Trigeminal Neuralgia
Weill Medical College of Cornell University
 2020-10 PHASE1
NCT04429022 COMPLETED
Pain, Postoperative
State University of New York at Buffalo
 2020-11-24 PHASE3
NCT05607641 COMPLETED
Postsurgical Pain
Darnitsa Pharmaceutical Company
 2021-07-07 PHASE2; PHASE3
NCT03987022 COMPLETED
Opioid Substitution Treatment
MetroHealth Medical Center
 2019-08-01 PHASE4
NCT03584373 COMPLETED
Nephrolithiasis
Montefiore Medical Center
 2018-07-27 PHASE3
NCT05383820 UNKNOWN
Malocclusion; Pain, Acute
University of Guadalajara
 2021-09-27 PHASE4
NCT03805607 COMPLETED
Analgesia, Obstetrical; Coagulation Defect; Postpartum; Nonsteroidals (NSAIDs)Toxicity; Postpartum Hemorrhage; Postoperative Pain; Ketorolac Adverse Reaction; Blood Loss, Postoperative
Beth Israel Deaconess Medical Center
 2021-01-18 PHASE4
NCT04441762 COMPLETED
Acute Renal Colic
Oman Medical Speciality Board
 2020-12-30 PHASE2; PHASE3
NCT05695664 COMPLETED
Intravenous Drug Usage; Ibuprofen; Ketorolac; Knee Arthroscopy; Postoperative Pain
Benazir Bhutto Hospital, Rawalpindi
 2021-08-01 EARLY_PHASE1
NCT03678675 COMPLETED
Post-operative Pain; Post-partum Pain; Cesarean Section Complications
Tufts Medical Center
 2019-05-30 PHASE3
NCT05097768 COMPLETED
Symptomatic Irreversible Pulpitis
Alfarabi Colleges
 2021-08-15
NCT05994287 COMPLETED
Postoperative Pain, Acute
Federal State Budgetary Organization, Federal Center for Traumatology, Orthopedics and Arthroplasty
 2021-01-01
NCT02700451 COMPLETED
Lumbar Osteoarthritis; Spondylosis; Lumbar Disc Disease; Spinal Stenosis
Hospital for Special Surgery, New York
 2016-03
NCT04872283 UNKNOWN
Ketorolac; Joint Fusion
Rothman Institute Orthopaedics
 2019-05-23 PHASE3
NCT03066115 WITHDRAWN
Hypoxia; Hypercapnia
University of Wisconsin, Madison
 2020-12-01 PHASE1
NCT04282200 UNKNOWN
Acute Pancreatitis
University of Cincinnati
 2020-02-24 PHASE4
NCT01571791 SUSPENDED
Valve Heart Disease; Elective Cesarean Delivery
Mansoura University
 2012-06 PHASE2
NCT06484439 COMPLETED
Pain, Post-operative; Third Molar; Oral Surgery; Pain, Acute
United States Naval Medical Center, San Diego
 2018-02-14 EARLY_PHASE1
NCT04133623 COMPLETED
Acute Pain Due to Trauma
IRCCS Burlo Garofolo
 2019-11-19 PHASE3
NCT04444830 WITHDRAWN
Post Operative Pain Control; Narcotic Use; Pelvic Organ Prolapse; Urinary Incontinence , Stress; Surgery
University of Louisville
 2021-01 PHASE4
NCT04246541 COMPLETED
Meniscus Tear, Tibial; Pain, Postoperative; Postoperative Complications; Ketorolac Adverse Reaction; Opioid Use
University Hospitals Cleveland Medical Center
 2019-04-23 PHASE3
NCT03534505 TERMINATED
Inguinal Herniorrhaphy; Pain, Postoperative
Mahidol University
 2018-07-01
NCT05180214 COMPLETED
Thyroid Goiter; Thyroid Nodule
Sohag University
 2021-01-17 PHASE2
NCT03888144 COMPLETED
Kidney Calculi; Ureteral Calculi
The Cleveland Clinic
 2017-10-13 PHASE4
NCT04380298 UNKNOWN
Pain; Supratentorial Brain Tumor
Beijing Tiantan Hospital
 2020-12-01 PHASE4
NCT04319549 UNKNOWN
Acute Irreversible Pulpitis With Apical Periodontitis
Cairo University
 2020-08-01
NCT05361824 COMPLETED
Coronary Artery Disease; Post Operative Pain; Analgesia; Coronary Artery Bypass Grafting Surgery
National Institute of Cardiovascular Diseases, Pakistan
 2021-01-01 PHASE4
NCT03864133 COMPLETED
Cataract
Wake Forest University Health Sciences
 2019-07-08 PHASE4
NCT03693404 COMPLETED
Pertrochanteric Fracture
NYU Langone Health
 2018-12-01 PHASE4
NCT02358681 COMPLETED
Migraine
Columbia University
 2015-06-16 PHASE3
NCT02570503 TERMINATED
Osteoarthritis, Knee
Virginia Commonwealth University
 2015-10 PHASE4
NCT03861611 COMPLETED
Back Pain Without Radiation; Low Back Pain
Montefiore Medical Center
 2019-07-12 PHASE4
NCT04137770 TERMINATED
Pain, Postoperative
Mercy Research
 2020-02-04
NCT03818919 COMPLETED
Rotator Cuff Tear
Henry Ford Health System
 2019-01-22 PHASE2
NCT04618497 COMPLETED
Acute Traumatic Pain
Hospital Authority, Hong Kong
 2020-10-28 PHASE3
NCT04763876 COMPLETED
Musculoskeletal Pain; Analgesia; Adverse Event
William Beaumont Army Medical Center
 2020-06-27 PHASE4
NCT03967847 COMPLETED
Rotator Cuff Tear; Postoperative Pain
University Hospitals Cleveland Medical Center
 2019-02-11 PHASE3
NCT04246554 COMPLETED
ACL Injury; Postoperative Pain
University Hospitals Cleveland Medical Center
 2019-05-21 PHASE3
NCT04554862 COMPLETED
Postoperative Pain
Fayoum University Hospital
 2019-10-01 PHASE4
NCT03319784 WITHDRAWN
Rotator Cuff Tear; Rotator Cuff Injury; Rotator Cuff Tendinitis; Diabetes Mellitus
Milton S. Hershey Medical Center
 2018-09-05 PHASE4
NCT05248724 COMPLETED
Anterior Cruciate Ligament Reconstruction
Castilla-La Mancha Health Service
 2017-08-01
NCT03820193 COMPLETED
Meniscus Disorder; Narcotic Use
Henry Ford Health System
 2019-01-22 EARLY_PHASE1
NCT02276495 COMPLETED
Pain Management
University of California, Irvine
 2015-01-01
NCT04651556 COMPLETED
Intraperitoneal Magnesium Sulphate in Laparoscope in Pediatrics
Menoufia University
 2019-04-04 PHASE4
NCT03472872 WITHDRAWN
Headache
Corewell Health South
 2017-09-05 PHASE4
NCT03393364 COMPLETED
Urologic Diseases
University Hospitals Cleveland Medical Center
 2018-04-01 EARLY_PHASE1
NCT03221569 UNKNOWN
Migraine
The Brooklyn Hospital Center
 2016-02-01 PHASE4
NCT03825809 RECRUITING
Narcotic Use
Henry Ford Health System
 2019-01-22 PHASE2; PHASE3
NCT03818932 COMPLETED
Anterior Cruciate Ligament Injury
Henry Ford Health System
 2019-01-22 PHASE2; PHASE3
NCT03066544 UNKNOWN
Migraine
Hartford HealthCare
 2016-11-30 PHASE1; PHASE2
NCT03851172 UNKNOWN
Cataract; Miosis
Assiut University
 2019-03-01 PHASE2
NCT03017430 COMPLETED
Opioid Withdrawal
St. Petersburg Bekhterev Research Psychoneurological Institute
 2014-01 PHASE4
NCT03968146 COMPLETED
Scoliosis Idiopathic; Scoliosis; Adolescence; Erector Spinae Plane Block
Kasr El Aini Hospital
 2019-06-18 PHASE2
NCT03665753 COMPLETED
Pain; Renal Colic
Tehran University of Medical Sciences
 2018-11-05 EARLY_PHASE1
NCT03619785 UNKNOWN
Rib Fractures; Rib Fracture Multiple
Andrew A Herring
 2018-11-06 PHASE4
NCT04441112 COMPLETED
Arthritis Knee; Arthritis of Hip
Saint Alphonsus Regional Medical Center
 2018-05-20 PHASE2; PHASE3
NCT03585894 COMPLETED
Headache
Danish Headache Center
 2018-08-01
NCT03694821 TERMINATED
Osteoarthritis
UConn Health
 2018-07-05 PHASE4
NCT03943199 COMPLETED
Scorpion Stings; Pain; Analgesic
Mexican Red Cross
 2019-05-05
NCT03472469 COMPLETED
Nonspecific Pain Post Traumatic Injury
The University of Texas Health Science Center, Houston
 2018-04-02 PHASE4
NCT03885596 COMPLETED
Pain
Concentric Analgesics
 2019-03-25 PHASE2
NCT03789227 COMPLETED
Pain, Chronic
Mansoura University
 2018-07-01
NCT04112160 COMPLETED
Pain; Urinary Stone; Urinary Calculi
University of Texas Southwestern Medical Center
 2018-06-28 PHASE2
NCT03836781 COMPLETED
Chronic Periodontitis
Amirhossein Farahmand
 2018-04-10 PHASE2; PHASE3
NCT04322968 COMPLETED
PTSD; Chronic Pain
VA Ann Arbor Healthcare System
 2018-01-09 PHASE3
NCT03586934 WITHDRAWN
Shoulder Pain; Opioid Use
Rush University Medical Center
 2018-06-01 PHASE3
NCT03028012 TERMINATED
Myofascial Pain
University of Utah
 2017-05-02 PHASE4
NCT03742180 WITHDRAWN
Elective Bilateral Myringotomy
Mansoura University
 2018-01-01
NCT03485625 COMPLETED
Postoperative Pain
Assiut University
 2018-03-21 PHASE3
NCT03426137 TERMINATED
Trauma; Opioid Use; Spine Fusion
University of Maryland, Baltimore
 2018-09-17 PHASE2
NCT03137498 UNKNOWN
Renal Colic
The Brooklyn Hospital Center
 2017-03-06 PHASE4
NCT02829944 COMPLETED
Pain
Duke University
 2016-11 PHASE4
NCT02885441 TERMINATED
Acute Pancreatitis
Ilam University of Medical Sciences
 2016-09 PHASE4
NCT02474654 COMPLETED
Knee Replacement, Total
Health Sciences North Research Institute
 2015-07 PHASE4
NCT03041935 COMPLETED
Testicle Undescended; Pain, Postoperative
Alberta Children's Hospital
 2015-09-01
NCT03007381 WITHDRAWN
Breast Cancer Female
Nova Scotia Health Authority
 2017-11 PHASE4
NCT03178539 COMPLETED
Pain, Acute
Assiut University
 2017-01-31 PHASE2; PHASE3
NCT01667120 WITHDRAWN
Postoperative Pain Control in Surgical Neonates
Nationwide Children's Hospital
 2012-07 PHASE2
NCT02895035 TERMINATED
Cataract
Milton S. Hershey Medical Center
 2016-09-01 PHASE4
NCT03695367 COMPLETED
Postoperative Pain
Heron Therapeutics
 2018-10-01 PHASE2
NCT03599089 COMPLETED
Post-surgical Pain
Concentric Analgesics
 2018-07-09 PHASE2
NCT02470299 COMPLETED
Ovarian Cancer; Fallopian Tube Cancer; Peritoneal Cancer
New Mexico Cancer Research Alliance
 2015-10-29
NCT02902770 COMPLETED
Pain
Antonios Likourezos
 2016-10 PHASE4
NCT03649334 COMPLETED
Hematological Malignancy (Leukemia- Lymphoma)
Mansoura University
 2018-08-26 PHASE4
NCT03669081 COMPLETED
Pain, Postoperative
University of Utah
 2016-09-20 PHASE2
NCT03041948 UNKNOWN
Hernia, Inguinal; Pain, Postoperative
Alberta Children's Hospital
 2015-09-01
NCT02543801 COMPLETED
Total Hip and Knee Arthroplasty
Kootenai Health
 2016-01-25 PHASE4
NCT03410212 COMPLETED
Symptomatic Irreversible Pulpitis
Azad University of Medical Sciences
 2018-02-15 PHASE2
NCT02266433 TERMINATED
DeQuervains Tenosynovitis; Lateral Epicondylitis; Tennis Elbow; Trigger Finger; Tenosynovitis; Inflammatory Disease
NYU Langone Health
 2012-08 PHASE3
NCT02344225 COMPLETED
Retinopathy of Prematurity
State University of New York - Downstate Medical Center
 2015-01-01 PHASE2
NCT02973958 COMPLETED
Pain, Postoperative; Phimosis; Paraphimosis; Balanitis
Alberta Children's Hospital
 2017-02-01 PHASE1
NCT02956616 COMPLETED
Cesarean Section
Montefiore Medical Center
 2017-09-01 PHASE2
NCT04119921 COMPLETED
DME
Shahid Beheshti University of Medical Sciences
 2018-01-01 PHASE2; PHASE3
NCT03394001 UNKNOWN
Anesthesia
Ain Shams University
 2018-01-01 PHASE4
NCT03323684 COMPLETED
Laparoscopic Cholecystectomy
Mansoura University
 2017-10-01
NCT03727048 COMPLETED
Ankle Fractures; Trauma Injury
Rothman Institute Orthopaedics
 2016-08 PHASE4
NCT02987920 TERMINATED
Pain, Postoperative
University of Southern California
 2017-01 PHASE4
NCT02540070 UNKNOWN
Osteoarthritis; Knee Arthroplasty; Pain Management
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
 2014-08 PHASE3
NCT02958566 UNKNOWN
Colon Cancer; Colon Diverticulosis; Colonic Neoplasms; Colonic Diverticulitis; Pain, Postoperative; Ileus; Ileus Paralytic; Ileus; Mechanical; Constipation Drug Induced; Constipation; Rectum Cancer; Rectum Neoplasm
University of Illinois College of Medicine at Peoria
 2017-01 PHASE4
NCT02297906 TERMINATED
Evaluating Pharmacokinetics of Intranasal Ketorolac; Pain
Columbia University
 2015-02 PHASE1
NCT02612272 UNKNOWN
Knee Osteoarthritis
St. Luke's Hospital, Pennsylvania
 2015-11 PHASE4
NCT03032458 COMPLETED
Analgesia; Urolithiasis
Mansoura University
 2017-01 PHASE4
NCT02509312 COMPLETED
Analgesia, Obstetrical; Postpartum Hemorrhage; Opioid Use; Nonsteroidals (NSAIDs)Toxicity; Coagulation Defect; Postpartum; Postoperative Pain; Ketorolac Adverse Reaction; Blood Loss, Postoperative
University Hospitals Cleveland Medical Center
 2016-05 PHASE4
NCT02940405 UNKNOWN
Irreversible Pulpitis
Cairo University
 2017-01
NCT04115644 TERMINATED
Full Thickness Rotator Cuff Tear; Rotator Cuff Tendinitis
Michael Khazzam
 2017-05-01 PHASE4
NCT03025594 UNKNOWN
Knee Arthroplasty; Pain Management
maximiliano barahona vasquez
 2017-01 PHASE3
NCT02664116 UNKNOWN
Migraine Headache
Scripps Health
 2016-01 PHASE4
NCT03767036 COMPLETED
Pharmacokinetics
Grünenthal GmbH
 2017-06-05 PHASE1
NCT03551808 UNKNOWN
Cystoid Macular Edema After Phacoemulsification
Shahid Beheshti University of Medical Sciences
 2017-01-01 PHASE2
NCT02922985 COMPLETED
Pain
The University of Texas Medical Branch, Galveston
 2016-10 PHASE4
NCT02465255 COMPLETED
Abdominal Pain
IRCCS Burlo Garofolo
 2015-03 PHASE3
NCT02658149 COMPLETED
Osteoarthritis; Arthroplasty
Corewell Health East
 2016-05 PHASE4
NCT02313675 COMPLETED
Postoperative Pain; Carpal Tunnel Release; Distal Radius Fracture
John Fowler
 2015-05 PHASE4
NCT02769325 UNKNOWN
Laparoscopic Surgery; Gynecology
Clinica Santa Maria
 2016-05 PHASE4
NCT02752646 COMPLETED
Cataract
MDbackline, LLC
 2016-04
NCT02923687 COMPLETED
Irreversible Pulpitis
Azad University of Medical Sciences
 2016-09 PHASE2
NCT03116672 COMPLETED
Pulpitis - Irreversible
Universidad Autonoma de Baja California
 2016-02-02
NCT01576276 COMPLETED
Healthy Controls
Massachusetts General Hospital
 2012-04
NCT02128646 COMPLETED
Pain
University of Kansas Medical Center
 2014-04 PHASE4
NCT02765815 WITHDRAWN
Osteoarthritis, Knee; Arthroplasty, Replacement, Knee
Holy Cross Hospital, Florida
 2016-02 PHASE4
NCT02181426 COMPLETED
Meniscectomy
Medical University of South Carolina
 2012-03
NCT03996564 COMPLETED
Low Back Pain, Mechanical
San Antonio Military Medical Center
 2016-02-22
NCT03143244 COMPLETED
Retinal Surgery
Mansoura University
 2016-01-01 PHASE4
NCT02953210 UNKNOWN
Pain, Postoperative; Anesthesia Complication; Nausea; Vomiting; Ileus Paralytic; Hemodynamic Instability
Federal University of São Paulo
 2016-11 PHASE4
NCT02647047 UNKNOWN
Secondary Malignant Neoplasm of Liver; Liver Diseases; Liver Neoplasms
Ospedale San Raffaele
 2016-01
NCT01609881 WITHDRAWN
Inflammation
Vanderbilt University
 2012-03 PHASE1
NCT02162121 COMPLETED
Hip Replacement Arthroplasty
ASST Gaetano Pini-CTO
 2014-05 PHASE4
NCT02782286 UNKNOWN
Low Back Pain
Loredana Ghinea
 2016-05 PHASE4
NCT02568995 COMPLETED
Postoperative Pain Intensity; Rescue Pain Requirements
Örebro University, Sweden
 2014-05 PHASE3
NCT02782273 UNKNOWN
Renal Colic
Loredana Ghinea
 2016-05 PHASE4
NCT02242201 COMPLETED
Total Hip Arthroplasty
Mayo Clinic
 2014-09 PHASE4
NCT03081416 COMPLETED
Headache; Intranasal Ketamine
Brooke Army Medical Center
 2016-05 PHASE3
NCT02867176 COMPLETED
Pain
Instituto de Oftalmología Fundación Conde de Valenciana
 2016-01 PHASE4
NCT03331315 COMPLETED
Pain, Postoperative
Michael Ulm, MD
 2013-09-01 PHASE2
NCT02881996 COMPLETED
Perforated Appendicitis
Children's Mercy Hospital Kansas City
 2014-06
NCT02614118 COMPLETED
Irreversible Pulpitis
Azad University of Medical Sciences
 2015-09 PHASE2
NCT02112448 COMPLETED
Congenital Heart Disease
Wake Forest University Health Sciences
 2014-06
NCT02400645 TERMINATED
Postoperative Pain
University of Tennessee
 2015-03 PHASE1
NCT02691572 COMPLETED
Postcesarean Analgesia
Mansoura University
 2016-02
NCT02601911 COMPLETED
Irreversible Pulpitis
Azad University of Medical Sciences
 2015-09 PHASE2
NCT03031795 COMPLETED
Contraception
OhioHealth
 2014-07 PHASE4
NCT02327923 COMPLETED
Gall Stone Disease
B.P. Koirala Institute of Health Sciences
 2015-01 PHASE4
NCT02937896 COMPLETED
Renal Colic
Shahid Beheshti University of Medical Sciences
 2015-01
NCT02141139 UNKNOWN
Breast Neoplasms
Samsung Medical Center
 2014-09 PHASE3
NCT01670799 COMPLETED
Fallopian Tube Cancer; Ovarian Cancer; Peritoneal Cavity Cancer
New Mexico Cancer Research Alliance
 2012-03 EARLY_PHASE1
NCT03224637 COMPLETED
Osteo Arthritis Knee; Pain, Chronic
Assiut University
 2014-07
NCT02078492 COMPLETED
Pain
Antonios Likourezos
 2014-03 PHASE4
NCT02039427 COMPLETED
Anesthesia Intubation Complication; Tracheal Disease
Yeungnam University College of Medicine
 2014-01
NCT01806259 COMPLETED
Curative Breast Cancer Surgery; Inflammatory Positive/Negative Status; Pre Surgical Incision Administration
Université Catholique de Louvain
 2013-02 PHASE3
NCT02380898 COMPLETED
Cesarean Section
Assiut University
 2015-03 PHASE4
NCT00981435 COMPLETED
Glaucoma
Stanford University
 2009-09 PHASE4
NCT02082067 WITHDRAWN
Total Knee Arthroplasty
ASST Gaetano Pini-CTO
 2014-03 PHASE4
NCT02536430 COMPLETED
Failed Mechanical Induction
Nahid Mohammadzadeh Akhlaghi
 2015-03 PHASE2
NCT02102516 COMPLETED
Pain
Egalet Ltd
 2014-03 PHASE3
NCT02646072 COMPLETED
Cystoid Macular Edema, Postoperative; Diabetes Mellitus
University of Malaya
 2014-08 PHASE4
NCT02476799 COMPLETED
Gynecologic Disease
Ewha Womans University Mokdong Hospital
 2014-11
NCT02449954 UNKNOWN
Breast Cancer
Assiut University
 2014-06 PHASE2; PHASE3
NCT02860949 COMPLETED
Osteoarthritis, Knee
Thammasat University
 2014-04 PHASE2
NCT00900887 COMPLETED
Diabetic Retinopathy; Macular Edema
Hospital Juarez de Mexico
 2008-04 PHASE2
NCT02312739 COMPLETED
Contraception; Inhalation of Nitrous Oxide
University of New Mexico
 2014-02
NCT00907114 COMPLETED
Proliferative Diabetic Retinopathy; Macular Edema
Hospital Juarez de Mexico
 2009-06 PHASE2
NCT01807234 COMPLETED
Migraines
Johns Hopkins University
 2013-02 PHASE4
NCT02361645 COMPLETED
Vitreous Inflammation
Università degli Studi di Brescia
 2014-03 PHASE3
NCT02729285 COMPLETED
Pain
Sun Yat-sen University
 2014-07 PHASE4
NCT00774540 COMPLETED
Knee Injuries
Oslo University Hospital
 2008-08 PHASE4
NCT01901393 COMPLETED
Pain
Cumberland Pharmaceuticals
 2013-07 PHASE4
NCT01736358 TERMINATED
Postoperative Pain Management; Urolithiasis
Montefiore Medical Center
 2012-10 PHASE4
NCT02295189 COMPLETED
Knee Osteoarthritis
San Antonio Military Medical Center
 2013-01
NCT01596166 COMPLETED
Probable Migraine; Migraine With Aura; Migraine Without Aura
University of Alberta
 2012-02 PHASE4
NCT01664559 COMPLETED
Pain Control With IUD Insertion
Lynn Ngo
 2012-07
NCT01819610 COMPLETED
Pain
American Regent, Inc.
 2013-02 PHASE3
NCT02169856 COMPLETED
Postoperative Nausea and Vomiting
Benazir Bhutto Hospital, Rawalpindi
 2013-07
NCT02162134 COMPLETED
Postoperative Ileus.
Benazir Bhutto Hospital, Rawalpindi
 2013-01
NCT01304212 COMPLETED
Pain
Jose Antonio Bernia Gil
 2011-04 PHASE4
NCT00478036 TERMINATED
Open Angle Glaucoma
University of Colorado, Denver
 2007-05
NCT02508857 COMPLETED
Pain, Postoperative
Instituto do Cancer do Estado de São Paulo
 2010-01 PHASE4
NCT02060604 COMPLETED
Wet Macular Degeneration
Università degli Studi di Brescia
 2012-12 PHASE4
NCT01543165 UNKNOWN
Renal Colic
Seoul National University Hospital
 2012-12 PHASE4
NCT01471899 COMPLETED
Back Pain
EMS
 2013-03 PHASE3
NCT02000388 UNKNOWN
Post Vasectomy Pain
Citrus Valley Medical Research, Inc.
 2012-02 PHASE4
NCT01374828 WITHDRAWN
Pain, Postoperative
The Cleveland Clinic
 2012-01 PHASE4
NCT02638831 COMPLETED
Gonarthrosis; Low Back Pain
Dr. Reddy's Laboratories Limited
 2013-03 PHASE4
NCT01471886 COMPLETED
Back Pain
EMS
 2013-03 PHASE3
NCT02084576 COMPLETED
Cystoid Macular Edema; Cataract
Hospital Oftalmologico de Brasilia
 2013-08 PHASE4
NCT02000401 COMPLETED
Interstitial Cystitis
Citrus Valley Medical Research, Inc.
 2012-05 PHASE4
NCT00621530 TERMINATED
Hip Arthroplasty
Wake Forest University
 2008-03 PHASE2
NCT01836406 COMPLETED
Renal Cell Carcinoma
Yonsei University
 2012-12
NCT01498796 TERMINATED
Recurrent Acute Tonsillitis
University of Alberta
 2009-09 PHASE2
NCT01799863 COMPLETED
Conjunctivitis, Viral
Fundação Altino Ventura
 2012-06 PHASE2; PHASE3
NCT01267864 COMPLETED
Acute Migraine
Montefiore Medical Center
 2010-11 PHASE4
NCT01859585 COMPLETED
Postoperative Pain
Prince of Songkla University
 2011-03 PHASE4
NCT01650519 COMPLETED
Arthroscopic Knee Surgery
Cumberland Pharmaceuticals
 2012-09 PHASE4
NCT01514175 UNKNOWN
Chronic Pelvic Pain
Culpeper Surgery Center
 2012-01 PHASE4
NCT01542190 COMPLETED
Cystoid Macular Edema Following Cataract Surgery, Bilateral
University of Campinas, Brazil
 2011-02 PHASE4
NCT01761071 COMPLETED
Myopes Who Have Undergone PRK.
Yonsei University
 2012-01 PHASE3
NCT01011673 COMPLETED
Headache
Montefiore Medical Center
 2009-11 PHASE4
NCT01490931 COMPLETED
Acute Pain
Hersh, Elliot V., DMD, MS, PhD
 2011-11 PHASE4
NCT01471639 COMPLETED
Other Acute Pain
The Cleveland Clinic
 2011-11
NCT01595282 COMPLETED
Pain
Planned Parenthood League of Massachusetts
 2011-06
NCT01305733 UNKNOWN
Pain
Coxa, Hospital for Joint Replacement
 2011-03
NCT01345162 COMPLETED
Hernia
Fondazione IRCCS Policlinico San Matteo di Pavia
 2010-03 PHASE4
NCT00560443 COMPLETED
Fracture; Pain
IRCCS Burlo Garofolo
 2008-02 PHASE4
NCT00974753 COMPLETED
Macular Edema
Queen's University
 2010-03
NCT01436032 TERMINATED
Laparoscopic Surgery
Alkermes, Inc.
 2011-10 PHASE3
NCT01133639 TERMINATED
Bunion
Beth Israel Deaconess Medical Center
 2010-05
NCT01534806 WITHDRAWN
Migraine
Akron Children's Hospital
 2012-01 PHASE4
NCT01832311 COMPLETED
Cataract; Type 2 Diabetes Mellitus
University of Zagreb
 2009-01 PHASE4
NCT01230463 UNKNOWN
Pain; Pain, Postoperative
University of Calgary
 2010-09
NCT01291472 COMPLETED
Postoperative Pain
Universitaire Ziekenhuizen KU Leuven
 2011-06 PHASE4
NCT00865540 UNKNOWN
Cataract
Clinica Oftamologica Zona Sul
 2009-03 PHASE4
NCT01560767 COMPLETED
Knee Arthritis
University of Warwick
 2010-10 PHASE4
NCT00868348 COMPLETED
Postoperative Pain
University of Aarhus
 2009-05 PHASE4
NCT01344395 COMPLETED
Pain, Postoperative; Pain
University of Aarhus
 2010-03 PHASE4
NCT01395069 COMPLETED
Macular Edema
Queen's University
 2010-02 PHASE4
NCT00992082 UNKNOWN
Osteoarthritis
Region Örebro County
 2009-08
NCT01258309 COMPLETED
Rhinitis, Allergic, Seasonal; Conjunctivitis, Allergic
Allergan
 2010-12 PHASE3
NCT01164085 COMPLETED
Inflammation
Vanderbilt University
 2009-12 PHASE1
NCT00765232 COMPLETED
Nephrectomy; Laparoscopic Donor Nephrectomy
Mayo Clinic
 2008-10 PHASE4
NCT01322191 COMPLETED
Post Operative Pain
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
 2008-04 PHASE4
NCT00765128 COMPLETED
Renal Calculus; Kidney Stones
Mayo Clinic
 2008-10 PHASE4
NCT00693160 TERMINATED
Healthy
Wake Forest University
 2007-12 PHASE2
NCT01081535 COMPLETED
Ureteroneocystostomy
Yonsei University
 2009-05
NCT01015235 COMPLETED
Pain, Postoperative
KAI Pharmaceuticals
 2008-12 PHASE2
NCT01023724 COMPLETED
Post Operative Anterior Chamber Inflammation (Flare)
Bucci Laser Vision Institute
 2009-12 PHASE4
NCT01103401 COMPLETED
Cataract
Veroia General Hospital
 2009-10
NCT00956462 UNKNOWN
Glaucoma
University Health Network, Toronto
 2007-07
NCT01021761 COMPLETED
Cataracts
Frank A. Bucci, Jr., M.D.
 2009-10 PHASE4
NCT01001806 COMPLETED
Cataracts
Frank A. Bucci, Jr., M.D.
 2009-10 PHASE4
NCT01242644 COMPLETED
Pain
University of South Alabama
 2006-10 PHASE2
NCT01339624 COMPLETED
Acute Renal Colic
Valduce Hospital
 2009-01
NCT00791323 COMPLETED
Inflammation
Allergan
 2008-11 PHASE4
NCT03693183 WITHDRAWN
Dry Eye
ORA, Inc.
 2009-03 PHASE2
NCT00904904 COMPLETED
Cataract; Inflammation
Bausch & Lomb Incorporated
 2008-04 PHASE4
NCT00485108 COMPLETED
Primary Open Angle Glaucoma; Pseudoexfoliation Glaucoma
Queen's University
 2007-01
NCT00562627 COMPLETED
Osteoarthritis of the Knee
Asker & Baerum Hospital
 2007-11 PHASE4
NCT00707421 COMPLETED
Glaucoma; Trabeculectomy; Fibrosis; Intraocular Pressure
Universitaire Ziekenhuizen KU Leuven
 2005-07 PHASE3
NCT00617097 COMPLETED
Pain; Surgical Abortion
Johns Hopkins University
 2008-01 PHASE2; PHASE3
NCT00785863 COMPLETED
Hyperalgesia, Secondary
Ullevaal University Hospital
 2008-12 PHASE4
NCT00992355 COMPLETED
Cataract
Veroia General Hospital
 2009-01
NCT00595543 COMPLETED
Acute Pseudophakic Cystoid Macular Edema
Bp Consulting, Inc
 2008-01 PHASE4
NCT00901628 COMPLETED
Osteoarthritis, Knee
Seoul National University Hospital
 2008-04 PHASE4
NCT00507026 COMPLETED
Postoperative Pain
Pfizer
 2007-07-25 PHASE3
NCT00405262 COMPLETED
Postoperative Pain
The Hospital for Sick Children
 2006-05 PHASE3
NCT00603083 COMPLETED
Pain, Postoperative
Vejle Hospital
 2008-01 PHASE4
NCT00115336 TERMINATED
Hematologic Diseases; Anemia, Sickle Cell
Children's Hospital Medical Center, Cincinnati
 2005-01 PHASE4
NCT00638508 COMPLETED
Postoperative Pain
Maimonides Medical Center
 2007-06 PHASE4
NCT00520260 COMPLETED
Dry Eye Disease; Ocular Comfort
Florida Eye Microsurgical Institute
 2007-08 PHASE4
NCT00799175 COMPLETED
Postoperative Pain
Region Örebro County
 2007-04
NCT00469690 COMPLETED
Cataract
Innovative Medical
 2007-05 PHASE4
NCT01365624 COMPLETED
Healthy Subjects
American Regent, Inc.
 2008-02 PHASE1
NCT00524264 COMPLETED
Cataract Extraction; Pain; Inflammation
Allergan
 2007-10 PHASE3
NCT01260883 COMPLETED
Postoperative Pain in Infants
Seattle Children's Hospital
 2000-05 PHASE3
NCT00421967 TERMINATED
Arthroplasty, Replacement, Knee
University of Aarhus
 2007-01 PHASE4
NCT00521456 COMPLETED
Cataract Extraction
Allergan
 2007-10 PHASE3
NCT01365650 COMPLETED
Allergic Rhinitis
Egalet Ltd
 2007-12 PHASE1
NCT01363076 COMPLETED
Postoperative Pain
Egalet Ltd
 2007-06 PHASE1
NCT00483717 COMPLETED
Migraine
Egalet Ltd
 2007-07 PHASE2
NCT00448110 COMPLETED
Pain, Postoperative
Javelin Pharmaceuticals
 2006-05 PHASE3
NCT00548678 COMPLETED
Healthy
Javelin Pharmaceuticals
 2007-10 PHASE1
NCT00335439 COMPLETED
Macular Edema, Cystoid
Queen's University
 2006-06
NCT01365611 COMPLETED
Healthy Subjects
Egalet Ltd
 2007-02 PHASE1
NCT00653926 COMPLETED
Postoperative Pain
Region Örebro County
 2005-09
NCT01363089 COMPLETED
Assess Pharmacokinetics of Ketorolac Tromethamine Intranasal and Assess Effects of a Oxymetazoline Hydrochloride on the PK of Ketorolac Tromethamine
Egalet Ltd
 2007-01 PHASE1
NCT01363063 COMPLETED
Healthy Volunteers
Egalet Ltd
 2006-12 PHASE1
NCT00266786 COMPLETED
Postoperative Pain
Egalet Ltd
 2005-12 PHASE3
NCT00332774 COMPLETED
Cataract
Alcon Research
 2006-02 PHASE3
NCT00405730 COMPLETED
Cataracts
Alcon Research
 2005-11 PHASE3
NCT00161577 COMPLETED
Pain Management Following Cardiopulmonary Bypass Surgery
Weill Medical College of Cornell University
 2004-01 PHASE4
NCT00330798 COMPLETED
Photorefractive Keratectomy
Alcon Research
 2006-02 PHASE4
NCT00293631 COMPLETED
Bunionectomy; Orthopedic Surgery
POZEN
 2005-11 PHASE2
NCT01363050 COMPLETED
Healthy Volunteers
Egalet Ltd
 2006-01 PHASE1
NCT00289419 COMPLETED
Arthroplasty, Replacement, Hip
University of Aarhus
 2005-02 PHASE4
NCT01355588 COMPLETED
Healthy Volunteers
Egalet Ltd
 2005-08 PHASE1
NCT01449448 WITHDRAWN
Subacromial Impingement Syndrome; Subacromial Bursitis
Madigan Army Medical Center
 2000-09
NCT01347853 COMPLETED
Postoperative Pain
Egalet Ltd
 2003-06 PHASE3
NCT01356225 COMPLETED
Pain; Dental Impaction
Egalet Ltd
 2004-02 PHASE2
NCT01356212 COMPLETED
Healthy Subjects
Egalet Ltd
 2002-09 PHASE1
NCT02642718 COMPLETED
Pain
Hospital Arquitecto Marcide
 2001-04 PHASE4
NCT00845754 COMPLETED
Febrile Morbidity; Pain
Ascher-Walsh, Charles, M.D.
 1999-09
NCT00348582 COMPLETED
Cataract
Innovative Medical
 PHASE4
NCT00377546 COMPLETED
Vitrectomy
Innovative Medical
 PHASE4
NCT00347204 COMPLETED
Myopia; Hyperopia
Center For Excellence In Eye Care
 2006-01 PHASE4
NCT00348244 COMPLETED
Cataract
Innovative Medical
 PHASE4
NCT01351090 COMPLETED
Postoperative Pain
American Regent, Inc.
 PHASE2
NCT00407017 COMPLETED
Cataract Surgery
Innovative Medical
 PHASE4
NCT00349401 WITHDRAWN
Pain
Wake Forest University Health Sciences
 2006-12 PHASE2
NCT00001698 COMPLETED
Leukoplakia; Periodontal Disease
National Cancer Institute (NCI)
 1998-06 PHASE2
NCT00433225 COMPLETED
Macula Thickening
Innovative Medical
 PHASE4
NCT00576329 COMPLETED
Surgery
Emory University
 2006-11 PHASE2; PHASE3
NCT00347503 COMPLETED
Cataract
Innovative Medical
 PHASE4

(data from https://clinicaltrials.gov, updated on 2025-10-24)

Check the Ketorolac product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Ketorolac acts as a non-selective inhibitor of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), thereby competitively blocking the conversion of arachidonic acid into pro-inflammatory prostaglandins. This inhibition suppresses local biochemical inflammatory cascades and pain pathways, mitigating fever, nociceptive signaling, and tissue swelling in clinical conditions such as postoperative pain, renal colic, and osteoarthritis.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.