CAS No. 74050-98-9
Batch:
Purity:99.84
Chemical Structure
Check the
Ketanserin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-1H-quinazoline-2,4-dione | |
|---|---|---|
| CAS Number | 74050-98-9 | |
| Molecular Formula |
C22H22FN3O3 |
|
| Molecular Weight (MW) | 395.43 | |
| SMILES | C1CN(CCC1C(=O)C2=CC=C(C=C2)F)CCN3C(=O)C4=CC=CC=C4NC3=O | |
| InChIKey | FPCCSQOGAWCVBH-UHFFFAOYSA-N |
Ketanserin is a specific 5-HT2A serotonin receptor antagonist (Ki = that also exhibits binding affinity for histamine H1 receptors (Ki = and alpha-1 adrenergic receptors (Ki ~. By blocking serotonin-mediated receptor signaling, it inhibits serotonin-induced platelet aggregation and vascular smooth muscle contraction, contributing to downstream vasodilation and reduced vascular resistance.
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
3 mg/mL
(7.58 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
2 mg/mL
(5.05 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
2 mg/mL
(5.05 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.