CAS No. 943540-75-8
| IUPAC Name | 6-[difluoro-[6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl]quinoline | |
|---|---|---|
| CAS Number | 943540-75-8 | |
| Molecular Formula |
C19H13F2N7 |
|
| Molecular Weight (MW) | 377.35 | |
| SMILES | CN1C=C(C=N1)C2=NN3C(=NN=C3C(C4=CC5=C(C=C4)N=CC=C5)(F)F)C=C2 | |
| InChIKey | JRWCBEOAFGHNNU-UHFFFAOYSA-N |
JNJ-38877605 is an ATP-competitive inhibitor targeting the c-Met receptor tyrosine kinase. By selectively inhibiting c-Met autophosphorylation and activation, it disrupts downstream HGF-stimulated signaling cascades, including the PI3K/AKT and MAPK/ERK pathways. This inhibition impairs key cellular phenotypes such as cancer cell proliferation, migration, invasion, and survival, ultimately suppressing tumor cell growth in c-Met-driven preclinical cancer models. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
50 mg/mL
(132.5 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
50 mg/mL
(132.5 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
| DMSO |
37 mg/mL
(98.05 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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