CAS No. 54-92-2
Batch:
Purity:99.85
Chemical Structure
Check the
Iproniazid
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N'-propan-2-ylpyridine-4-carbohydrazide | |
|---|---|---|
| CAS Number | 54-92-2 | |
| Molecular Formula |
C9H13N3O |
|
| Molecular Weight (MW) | 179.22 | |
| SMILES | CC(C)NNC(=O)C1=CC=NC=C1 | |
| InChIKey | NYMGNSNKLVNMIA-UHFFFAOYSA-N |
Iproniazid is a non-selective, irreversible monoamine oxidase (MAO) inhibitor that targets both MAO-A and MAO-B isoforms. By inhibiting MAO-mediated oxidative deamination, it prevents the enzymatic breakdown of monoamine neurotransmitters including serotonin, dopamine, and norepinephrine. This inhibition increases synaptic levels of monoamines in the central nervous system, leading to downstream enhanced monoaminergic neurotransmission and antidepressant phenotypes. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
35 mg/mL
(195.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 35 mg/mL |
| Ethanol | 35 mg/mL |
| DMSO |
36 mg/mL
(200.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 36 mg/mL |
| Ethanol | 36 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.