CAS No. 83-49-8

Batch: Purity:99.73
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Hyodeoxycholic acid (HDCA) Chemical Structure
Chemical Structure
Check the Hyodeoxycholic acid (HDCA) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (4R)-4-[(3R,5R,6S,8S,9S,10R,13R,14S,17R)-3,6-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
CAS Number 83-49-8
Molecular Formula

C24H40O4
Molecular Weight (MW) 392.57
SMILES CC(CCC(=O)O)C1CCC2C1(CCC3C2CC(C4C3(CCC(C4)O)C)O)C
InChIKey DGABKXLVXPYZII-SIBKNCMHSA-N

Biological Activity

Hyodeoxycholic acid (HDCA) is a secondary bile acid that functions in bile acid signaling through interactions with key bile acid receptors, including farnesoid X receptor (FXR) and G-protein-coupled receptor TGR5. Modulation of these bile acid receptor pathways regulates hepatic lipid metabolism and glucose homeostasis. Downstream activation of these signaling networks contributes to the regulation of metabolic homeostasis and intestinal microbial byproduct clearance. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 78 mg/mL (198.69 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 78 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Makishima M, et al. Science. 1999;284(5418):1362-5.

[2] Kawamata Y, et al. J Biol Chem. 2003;278(11):9435-40.

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Note: Technical data last updated: Sep 1, 2026.