CAS No. 1032754-93-0

Batch: Purity:99.76
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Apitolisib (GDC-0980) Chemical Structure
Chemical Structure
Check the Apitolisib (GDC-0980) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2S)-1-[4-[[2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one
CAS Number 1032754-93-0
Molecular Formula

C23H30N8O3S
Molecular Weight (MW) 498.6
SMILES CC1=C(SC2=C1N=C(N=C2N3CCOCC3)C4=CN=C(N=C4)N)CN5CCN(CC5)C(=O)C(C)O
InChIKey YOVVNQKCSKSHKT-HNNXBMFYSA-N

Ordering Information

Biological Activity

Apitolisib (GDC-0980) is a potent class I PI3K and mTOR dual inhibitor that selectively targets PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, and mTOR (Ki 1. By blocking the PI3K/AKT/mTOR pathway, apitolisib suppresses downstream signal transduction, induces G1 cell cycle arrest, and triggers both autophagy and apoptosis in cancer cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 27 mg/mL (54.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.