CAS No. 67-73-2

Batch: Purity:99.84
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Fluocinolone Acetonide Chemical Structure
Chemical Structure
Check the Fluocinolone Acetonide product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 67-73-2
Molecular Formula

C24H30F2O6

Molecular Weight (MW) 452.4999
SMILES CC1(OC2CC3C4CC(C5=CC(=O)C=CC5(C4(C(CC3(C2(O1)C(=O)CO)C)O)F)C)F)C

Ordering Information

Biological Activity

Fluocinolone acetonide is a synthetic corticosteroid that acts as an agonist of the cytosolic glucocorticoid receptor. Upon binding, the ligand-receptor complex translocates to the nucleus and interacts with glucocorticoid response elements to modulate target gene transcription. This pathway induces lipocortins and inhibits phospholipase A2, suppressing arachidonic acid release and decreasing downstream prostaglandin and leukotriene biosynthesis to exert anti-inflammatory activity. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 90 mg/mL (198.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 12 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.