CAS No. 2022-85-7

Batch: Purity:99.93
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Flucytosine (5-Fluorocytosine) Chemical Structure
Chemical Structure
Check the Flucytosine (5-Fluorocytosine) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 6-amino-5-fluoro-1H-pyrimidin-2-one
CAS Number 2022-85-7
Molecular Formula

C4H4FN3O
Molecular Weight (MW) 129.09
SMILES C1=NC(=O)NC(=C1F)N
InChIKey XRECTZIEBJDKEO-UHFFFAOYSA-N

Ordering Information

Biological Activity

Flucytosine (5-Fluorocytosine) is a synthetic fluorinated pyrimidine analogue with antifungal activity against Candida and Cryptococcus species. Intrafungally, flucytosine is converted by cytosine deaminase into 5-fluorouracil, which is further metabolized into 5-fluorodeoxyuridine monophosphate to inhibit thymidylate synthase and block DNA synthesis. Concurrently, conversion into 5-fluorouridine triphosphate leads to incorporation into fungal RNA, disrupting RNA biosynthesis and essential protein translation, ultimately inhibiting fungal cell growth. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 13 mg/mL (100.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 7 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.