CAS No. 79660-72-3
| CAS Number | 79660-72-3 | |
|---|---|---|
| Molecular Formula |
C17H18F3N3O3 |
|
| Molecular Weight (MW) | 369.34 | |
| SMILES | CN1CCN(CC1)C2=C(C=C3C(=C2F)N(C=C(C3=O)C(=O)O)CCF)F |
Fleroxacin is a broad-spectrum fluoroquinolone antibiotic that targets bacterial DNA gyrase and topoisomerase IV. By inhibiting these essential enzymes, fleroxacin blocks bacterial DNA replication and transcription, suppressing microbial cell proliferation. Additionally, fleroxacin demonstrates dose-dependent antiproliferative activity in cancer cell models and acts synergistically in combination with 5-fluorouracil to inhibit bladder tumor growth both in vitro and in vivo.
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| 0.1MNAOH | 2.5 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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