Fesoterodine Fumarate

For research use only.

Catalog No.S2240 Synonyms: SPM 907

1 publication

Fesoterodine Fumarate  Chemical Structure

CAS No. 286930-03-8

Fesoterodine Fumarate (SPM 907) is a prodrug of 5-hydroxymethyl tolterodine that is a muscarinic AChR receptor antagonist, used to treat overactive bladder syndrome.

Size Price Stock Quantity  
10mM (1mL in DMSO) GBP 343 In stock
GBP 63 In stock
GBP 79 In stock
GBP 104 In stock
GBP 384 In stock
GBP 483 In stock
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Selleck's Fesoterodine Fumarate has been cited by 1 publication

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Description Fesoterodine Fumarate (SPM 907) is a prodrug of 5-hydroxymethyl tolterodine that is a muscarinic AChR receptor antagonist, used to treat overactive bladder syndrome.
Targets
AChR [1]
In vitro

Fesoterodine is rapidly and extensively converted to 5-HMT, such that the pharmacologic activity appears to be primarily attributable to 5-HMT. [1] Fesoterodine is a competitive antagonist of cholinergic agonist-stimulated responses in human M1-M5 cell lines and has a similar potency and selectivity profile to the radioligand-binding studies. Fesoterodine causes a rightward shift of the concentration-response curve for carbachol with no depression of the maximum in rat bladder strips, and concentration-dependently reduces contractions induced by electrical field stimulation (EFS). [2] Fesoterodine is hydrolyzed by nonspecific esterases to 5-hydroxmethyl tolterodine (5-HMT), which is the active metabolite and is responsible for all its antimuscarinic activity. [3]

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (189.51 mM)
Water 100 mg/mL (189.51 mM)
Ethanol 100 mg/mL (189.51 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 527.65
Formula

C26H37NO3.C4H4O4

CAS No. 286930-03-8
Storage powder
in solvent
Synonyms SPM 907
Smiles CC(C)C(=O)OC1=C(C=C(C=C1)CO)C(CCN(C(C)C)C(C)C)C2=CC=CC=C2.C(=CC(=O)O)C(=O)O

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02385500 Terminated Drug: Fesoterodine|Drug: Placebo Urinary Bladder Overactive|Parkinson Disease Sir Mortimer B. Davis - Jewish General Hospital September 2016 Phase 4
NCT02614482 Completed Drug: Fesoterodine Overactive Bladder Stéphane Bolduc|Pfizer|CHU de Quebec-Universite Laval October 2015 Phase 3
NCT02327936 Completed Drug: Fesoterodine|Drug: Oxybutynin XL Overactive Bladder Stéphane Bolduc|Pfizer|CHU de Quebec-Universite Laval December 2014 Phase 3
NCT01286454 Completed Drug: fesoterodine Overactive Bladder (OAB) With Symptoms of Frequency Urgency and Urgency Pfizer December 2010 Phase 1
NCT00943735 Completed Drug: Fesoterodine|Behavioral: Your Way Overactive Bladder Pfizer July 2009 --

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AChR Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID