Fesoterodine Fumarate

Catalog No.S2240 Synonyms: SPM 907

For research use only.

Fesoterodine Fumarate (SPM 907) is a prodrug of 5-hydroxymethyl tolterodine that is a muscarinic AChR receptor antagonist, used to treat overactive bladder syndrome.

Fesoterodine Fumarate  Chemical Structure

CAS No. 286930-03-8

Selleck's Fesoterodine Fumarate has been cited by 1 Publication

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Biological Activity

Description Fesoterodine Fumarate (SPM 907) is a prodrug of 5-hydroxymethyl tolterodine that is a muscarinic AChR receptor antagonist, used to treat overactive bladder syndrome.
Targets
AChR [1]
In vitro

Fesoterodine is rapidly and extensively converted to 5-HMT, such that the pharmacologic activity appears to be primarily attributable to 5-HMT. [1] Fesoterodine is a competitive antagonist of cholinergic agonist-stimulated responses in human M1-M5 cell lines and has a similar potency and selectivity profile to the radioligand-binding studies. Fesoterodine causes a rightward shift of the concentration-response curve for carbachol with no depression of the maximum in rat bladder strips, and concentration-dependently reduces contractions induced by electrical field stimulation (EFS). [2] Fesoterodine is hydrolyzed by nonspecific esterases to 5-hydroxmethyl tolterodine (5-HMT), which is the active metabolite and is responsible for all its antimuscarinic activity. [3]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 527.65
Formula

C26H37NO3.C4H4O4

CAS No. 286930-03-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(C)C(=O)OC1=C(C=C(C=C1)CO)C(CCN(C(C)C)C(C)C)C2=CC=CC=C2.C(=CC(=O)O)C(=O)O

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02385500 Terminated Drug: Fesoterodine|Drug: Placebo Urinary Bladder Overactive|Parkinson Disease Sir Mortimer B. Davis - Jewish General Hospital September 2016 Phase 4
NCT02614482 Completed Drug: Fesoterodine Overactive Bladder Stéphane Bolduc|Pfizer|CHU de Quebec-Universite Laval October 2015 Phase 3
NCT02327936 Completed Drug: Fesoterodine|Drug: Oxybutynin XL Overactive Bladder Stéphane Bolduc|Pfizer|CHU de Quebec-Universite Laval December 2014 Phase 3
NCT01286454 Completed Drug: fesoterodine Overactive Bladder (OAB) With Symptoms of Frequency Urgency and Urgency Pfizer December 2010 Phase 1
NCT00943735 Completed Drug: Fesoterodine|Behavioral: Your Way Overactive Bladder Pfizer July 2009 --

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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