Fesoterodine Fumarate

Catalog No.S2240 Synonyms: SPM 907

For research use only.

Fesoterodine Fumarate (SPM 907) is a prodrug of 5-hydroxymethyl tolterodine that is a muscarinic AChR receptor antagonist, used to treat overactive bladder syndrome.

Fesoterodine Fumarate  Chemical Structure

CAS No. 286930-03-8

Selleck's Fesoterodine Fumarate has been cited by 1 Publication

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Biological Activity

Description Fesoterodine Fumarate (SPM 907) is a prodrug of 5-hydroxymethyl tolterodine that is a muscarinic AChR receptor antagonist, used to treat overactive bladder syndrome.
AChR [1]
In vitro

Fesoterodine is rapidly and extensively converted to 5-HMT, such that the pharmacologic activity appears to be primarily attributable to 5-HMT. [1] Fesoterodine is a competitive antagonist of cholinergic agonist-stimulated responses in human M1-M5 cell lines and has a similar potency and selectivity profile to the radioligand-binding studies. Fesoterodine causes a rightward shift of the concentration-response curve for carbachol with no depression of the maximum in rat bladder strips, and concentration-dependently reduces contractions induced by electrical field stimulation (EFS). [2] Fesoterodine is hydrolyzed by nonspecific esterases to 5-hydroxmethyl tolterodine (5-HMT), which is the active metabolite and is responsible for all its antimuscarinic activity. [3]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 527.65


CAS No. 286930-03-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(C)C(=O)OC1=C(C=C(C=C1)CO)C(CCN(C(C)C)C(C)C)C2=CC=CC=C2.C(=CC(=O)O)C(=O)O

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02385500 Terminated Drug: Fesoterodine|Drug: Placebo Urinary Bladder Overactive|Parkinson Disease Sir Mortimer B. Davis - Jewish General Hospital September 2016 Phase 4
NCT02614482 Completed Drug: Fesoterodine Overactive Bladder Stéphane Bolduc|Pfizer|CHU de Quebec-Universite Laval October 2015 Phase 3
NCT02327936 Completed Drug: Fesoterodine|Drug: Oxybutynin XL Overactive Bladder Stéphane Bolduc|Pfizer|CHU de Quebec-Universite Laval December 2014 Phase 3
NCT01286454 Completed Drug: fesoterodine Overactive Bladder (OAB) With Symptoms of Frequency Urgency and Urgency Pfizer December 2010 Phase 1
NCT00943735 Completed Drug: Fesoterodine|Behavioral: Your Way Overactive Bladder Pfizer July 2009 --

(data from https://clinicaltrials.gov, updated on 2022-08-01)

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