Catalog No.S2240 Synonyms: SPM 907
Molecular Weight(MW): 527.65
Fesoterodine Fumarate is a prodrug of 5-hydroxymethyl tolterodine that is a muscarinic AChR receptor antagonist, used to treat overactive bladder syndrome.
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|Description||Fesoterodine Fumarate is a prodrug of 5-hydroxymethyl tolterodine that is a muscarinic AChR receptor antagonist, used to treat overactive bladder syndrome.|
Fesoterodine is rapidly and extensively converted to 5-HMT, such that the pharmacologic activity appears to be primarily attributable to 5-HMT.  Fesoterodine is a competitive antagonist of cholinergic agonist-stimulated responses in human M1-M5 cell lines and has a similar potency and selectivity profile to the radioligand-binding studies. Fesoterodine causes a rightward shift of the concentration-response curve for carbachol with no depression of the maximum in rat bladder strips, and concentration-dependently reduces contractions induced by electrical field stimulation (EFS).  Fesoterodine is hydrolyzed by nonspecific esterases to 5-hydroxmethyl tolterodine (5-HMT), which is the active metabolite and is responsible for all its antimuscarinic activity. 
|In vitro||DMSO||100 mg/mL (189.51 mM)|
|Water||100 mg/mL (189.51 mM)|
|Ethanol||100 mg/mL (189.51 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02385500||Terminated||Drug: Fesoterodine|Drug: Placebo||Urinary Bladder Overactive|Parkinson Disease||Sir Mortimer B. Davis - Jewish General Hospital||September 2016||Phase 4|
|NCT02614482||Completed||Drug: Fesoterodine||Overactive Bladder||Stéphane Bolduc|Pfizer|CHU de Quebec-Universite Laval||October 2015||Phase 3|
|NCT02327936||Completed||Drug: Fesoterodine|Drug: Oxybutynin XL||Overactive Bladder||Stéphane Bolduc|Pfizer|CHU de Quebec-Universite Laval||December 2014||Phase 3|
|NCT01286454||Completed||Drug: fesoterodine||Overactive Bladder (OAB) With Symptoms of Frequency Urgency and Urgency||Pfizer||December 2010||Phase 1|
|NCT00943735||Completed||Drug: Fesoterodine|Behavioral: Your Way||Overactive Bladder||Pfizer||July 2009||--|
|NCT00786240||Completed||Drug: Fesoterodine||Healthy||Pfizer||January 2009||Phase 1|
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