CAS No. 936091-26-8
Batch:
Purity:99.99
Chemical Structure
Check the
Fedratinib (TG101348)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-tert-butyl-3-[[5-methyl-2-[4-(2-pyrrolidin-1-ylethoxy)anilino]pyrimidin-4-yl]amino]benzenesulfonamide | |
|---|---|---|
| CAS Number | 936091-26-8 | |
| Molecular Formula |
C27H36N6O3S |
|
| Molecular Weight (MW) | 524.68 | |
| SMILES | CC1=CN=C(N=C1NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)NC3=CC=C(C=C3)OCCN4CCCC4 | |
| InChIKey | JOOXLOJCABQBSG-UHFFFAOYSA-N |
Fedratinib (TG101348) is a potent, ATP-competitive inhibitor of JAK2 (IC50 3 nM), FLT3, and RET. By blocking JAK2 signaling, it suppresses downstream STAT5 phosphorylation, inhibits cell proliferation, and induces apoptosis in JAK2V617F-expressing hematopoietic cell lines. Furthermore, fedratinib reduces erythroid colony formation in polycythemia vera patient-derived cells and attenuates splenomegaly in animal models of myeloproliferative neoplasms. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(190.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(190.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(190.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(190.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 15 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(190.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Fedratinib (TG101348) Clinical Trials
- Fedratinib (TG101348) Solubility in DMSO
- Fedratinib (TG101348) Stock Solution
- Fedratinib (TG101348) Storage
- Fedratinib (TG101348) Stability
- Fedratinib (TG101348) Molecular Weight
- Fedratinib (TG101348) SMILES
- Fedratinib (TG101348) Chemical Structure (2D and 3D)
- Fedratinib (TG101348) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.