CAS No. 50-27-1
Batch:
Purity:99.34
Chemical Structure
Check the
Estriol
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 50-27-1 | |
|---|---|---|
| Molecular Formula |
C18H24O3 |
|
| Molecular Weight (MW) | 288.39 | |
| SMILES | CC12CCC3C(C1CC(C2O)O)CCC4=C3C=CC(=C4)O |
Biological Activity
Estriol is an endogenous estrogenic hormone that acts as a G-protein coupled estrogen receptor (GPER) antagonist in estrogen receptor-negative breast cancer cells. By inhibiting GPER-mediated signaling, estriol modulates downstream intracellular cascades including ERK and AKT pathways, thereby suppressing GPER-driven cell proliferation and migration. It serves as a key regulator in estrogen signaling networks and tumor cell responses. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
57 mg/mL
(197.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.