CAS No. 479-18-5

Batch: Purity:99.98
Check CoA
Dyphylline Chemical Structure
Chemical Structure
Check the Dyphylline product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 7-(2,3-dihydroxypropyl)-1,3-dimethylpurine-2,6-dione
CAS Number 479-18-5
Molecular Formula

C10H14N4O4
Molecular Weight (MW) 254.24
SMILES CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC(CO)O
InChIKey KSCFJBIXMNOVSH-UHFFFAOYSA-N

Biological Activity

Dyphylline is a xanthine derivative that acts as a phosphodiesterase inhibitor and adenosine receptor antagonist. By blocking adenosine receptors and inhibiting phosphodiesterase enzymes, it prevents cyclic nucleotide breakdown and raises intracellular cyclic adenosine monophosphate levels. This action modulates smooth muscle relaxation and vascular responses, promoting downstream bronchodilator and vasodilator phenotypes in respiratory signaling models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 51 mg/mL (200.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 51 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Free Aliquotting Service

Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.

Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.

Reference

[1] Clin Pharmacol Ther. 1981;30(6):830-838.

Jump to

Note: Technical data last updated: Sep 1, 2026.