CAS No. 164656-23-9

Batch: Purity:99.97
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Dutasteride Chemical Structure
Chemical Structure
Check the Dutasteride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-[2,5-bis(trifluoromethyl)phenyl]-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide
CAS Number 164656-23-9
Molecular Formula

C27H30F6N2O2
Molecular Weight (MW) 528.53
SMILES CC12CCC3C(C1CCC2C(=O)NC4=C(C=CC(=C4)C(F)(F)F)C(F)(F)F)CCC5C3(C=CC(=O)N5)C
InChIKey JWJOTENAMICLJG-QWBYCMEYSA-N

Ordering Information

Biological Activity

Dutasteride is a potent dual 5α-reductase inhibitor that targets both type 1 and type 2 5α-reductase isoforms. By inhibiting these enzyme isoforms, it blocks the conversion of testosterone into dihydrotestosterone (DHT), thereby blunting androgen receptor-mediated signaling pathways. Consequently, this suppression reduces prostate-specific antigen expression, inhibits cell proliferation, and promotes apoptosis in androgen-sensitive tissue.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 106 mg/mL (200.55 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 25 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.