CAS No. 54573-75-0

Batch: Purity:99.99
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Doxercalciferol Chemical Structure
Chemical Structure
Check the Doxercalciferol product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 54573-75-0
Molecular Formula

C28H44O2
Molecular Weight (MW) 412.65
SMILES CC(C)C(C)C=CC(C)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C

Ordering Information

Biological Activity

Doxercalciferol is a synthetic vitamin D2 analog that targets the vitamin D receptor (VDR) pathway. Upon enzymatic hydroxylation to its active metabolite, 1α,25-dihydroxyvitamin D2, it binds VDR to downregulate parathyroid hormone (PTH) gene expression and suppress parathyroid hormone synthesis and secretion. This pathway modulation inhibits parathyroid cell proliferation and reduces the progression of secondary hyperparathyroidism and associated metabolic bone disorders. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 83 mg/mL (201.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 70 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.