CAS No. 49745-95-1

Batch: Purity:99.86
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Dobutamine HCl Chemical Structure
Chemical Structure
Check the Dobutamine HCl product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[2-[4-(4-hydroxyphenyl)butan-2-ylamino]ethyl]benzene-1,2-diol;hydrochloride
CAS Number 49745-95-1
Molecular Formula

C18H23NO3·HCl
Molecular Weight (MW) 337.84
InChIKey BQKADKWNRWCIJL-UHFFFAOYSA-N

Ordering Information

Biological Activity

Dobutamine HCl is a potent and selective agonist of the β1-adrenergic receptor (β1-AR), while displaying significantly weaker activity toward α1-AR and β2-AR. Upon binding to β1-AR, it triggers downstream Gs protein-mediated adenylate cyclase activation, elevating intracellular cyclic AMP (cAMP) levels. This signaling cascade leads to enhanced calcium influx in cardiomyocytes, ultimately promoting myocardial contractility and increasing cardiac output. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 68 mg/mL (201.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.