CAS No. 512-04-9

Batch: Purity:99.77
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Diosgenin Chemical Structure
Chemical Structure
Check the Diosgenin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (1S,2S,4S,5'R,6R,7S,8R,9S,12S,13R,16S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-16-ol
CAS Number 512-04-9
Molecular Formula

C27H42O3
Molecular Weight (MW) 414.62
SMILES CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC=C6C5(CCC(C6)O)C)C)C)OC1
InChIKey WQLVFSAGQJTQCK-VKROHFNGSA-N

Ordering Information

Biological Activity

Diosgenin is a naturally occurring steroid sapogenin and weak phosphodiesterase (PDE) inhibitor. It suppresses cellular proliferation and induces apoptosis through modulation of key signaling cascades, including the upregulation of cyclooxygenase-2 (COX-2) in rheumatoid arthritis synoviocytes and suppression of NF-κB and AKT activation, ultimately inhibiting downstream pro-inflammatory and survival gene expression. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Ethanol 10 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.