CAS No. 97657-92-6

Batch: Purity:99.96
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Latrepirdine 2HCl Chemical Structure
Chemical Structure
Check the Latrepirdine 2HCl product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2,8-dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-3,4-dihydro-1H-pyrido[4,3-b]indole;dihydrochloride
CAS Number 97657-92-6
Molecular Formula

C21H25N3.2HCl
Molecular Weight (MW) 392.37
SMILES CC1=CC2=C(C=C1)N(C3=C2CN(CC3)C)CCC4=CN=C(C=C4)C.Cl.Cl
InChIKey GTWLIQOLGOZTLF-UHFFFAOYSA-N

Ordering Information

Biological Activity

Latrepirdine 2HCl is an orally active, neuroactive antagonist targeting multiple receptors, including histamine receptors, 5-HT receptors, AMPA, and NMDA glutamate receptors, as well as L-type calcium channels. It modulates mitochondrial permeability transition pores and enhances autophagy pathways. Through these combined mechanisms, latrepirdine reduces neurotoxic beta-amyloid protein accumulation and inhibits neurotoxicity to provide neuroprotective effects in neuronal cell models. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 78 mg/mL (198.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 26 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.