CAS No. 15307-79-6
| IUPAC Name | sodium 2-[2-(2,6-dichloroanilino)phenyl]acetate | |
|---|---|---|
| CAS Number | 15307-79-6 | |
| Molecular Formula |
C14H10Cl2NNaO2 |
|
| Molecular Weight (MW) | 318.13 | |
| SMILES | C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+] | |
| InChIKey | KPHWPUGNDIVLNH-UHFFFAOYSA-M |
Diclofenac sodium is a non-steroidal anti-inflammatory compound that acts as a non-selective inhibitor of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). By inhibiting COX isoenzymes, Diclofenac blocks the enzymatic conversion of arachidonic acid into prostaglandins, effectively suppressing downstream inflammatory signaling pathways. This reduction in prostaglandin production attenuates inflammatory responses, cellular proliferation, and COX-dependent pain and swelling phenotypes. [1][2]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
64 mg/mL
(201.17 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 64 mg/mL |
| Water | 14 mg/mL |
| DMSO |
64 mg/mL
(201.17 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 64 mg/mL |
| Water | 14 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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