CAS No. 149003-01-0
| IUPAC Name | 4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione;hydrochloride | |
|---|---|---|
| CAS Number | 149003-01-0 | |
| Molecular Formula |
C11H16N4O4.HCl |
|
| Molecular Weight (MW) | 304.73 | |
| SMILES | CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2.Cl | |
| InChIKey | BIFMNMPSIYHKDN-FJXQXJEOSA-N |
Dexrazoxane HCl is an intracellular iron chelator and topoisomerase II inhibitor that functions as a cardioprotective agent. By chelating free and bound iron within cells, it prevents the formation of toxic iron-anthracycline complexes and superoxide radicals. Additionally, its inhibition of topoisomerase II prevents anthracycline-induced DNA damage, mitigating downstream oxidative stress and preserving cardiac cell viability against doxorubicin toxicity. [1][2]
| Solvent | Solubility & Note |
|---|---|
| DMSO |
61 mg/mL
(200.17 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 61 mg/mL |
| Ethanol | Insoluble |
| DMSO |
60 mg/mL
(196.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 60 mg/mL |
| Ethanol | Insoluble |
| DMSO |
61 mg/mL
(200.17 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 61 mg/mL |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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