CAS No. 486-35-1
Batch:
Purity:99.55
Chemical Structure
Check the
Daphnetin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 7,8-dihydroxychromen-2-one | |
|---|---|---|
| CAS Number | 486-35-1 | |
| Molecular Formula |
C9H6O4 |
|
| Molecular Weight (MW) | 178.14 | |
| SMILES | C1=CC(=C(C2=C1C=CC(=O)O2)O)O | |
| InChIKey | ATEFPOUAMCWAQS-UHFFFAOYSA-N |
Daphnetin is a natural coumarin derivative and protein kinase inhibitor that suppresses EGFR (IC50 = 7.67 μM), PKA (IC50 = 9.33 μM), and PKC (IC50 = 25.01 μM). By inhibiting these protein kinases, daphnetin modulates downstream cellular signaling pathways involved in cell proliferation and survival. In addition to its protein kinase inhibitory effects, daphnetin exhibits anti-inflammatory and antioxidant activities.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
36 mg/mL
(202.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
36 mg/mL
(202.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
36 mg/mL
(202.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
36 mg/mL
(202.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
36 mg/mL
(202.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.