CAS No. 69-65-8

Batch: Purity:99.59
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D-Mannitol Chemical Structure
Chemical Structure
Check the D-Mannitol product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol
CAS Number 69-65-8
Molecular Formula

C6H14O6
Molecular Weight (MW) 182.17
SMILES C(C(C(C(C(CO)O)O)O)O)O
InChIKey FBPFZTCFMRRESA-KVTDHHQDSA-N

Biological Activity

D-Mannitol is an osmotic diuretic agent and weak renal vasodilator. It elevates intravascular osmolality, drawing fluid from parenchymal tissues into the vascular space to reduce swelling and preserve renal function. Furthermore, hypertonic mannitol induces transient disruption of the blood-brain barrier by shrinking vascular endothelial cells and opening tight junctions, thereby facilitating the enhanced delivery of therapeutic pharmaceuticals into the central nervous system. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 36 mg/mL (197.61 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 36 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Rapoport SI. Cell Mol Neurobiol. 2000;20(2):217-30.

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Note: Technical data last updated: Sep 1, 2026.