CAS No. 1056634-68-4
Batch:
Purity:99.01
Chemical Structure
Check the
Momelotinib (CYT387)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-(cyanomethyl)-4-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]benzamide | |
|---|---|---|
| CAS Number | 1056634-68-4 | |
| Molecular Formula |
C23H22N6O2 |
|
| Molecular Weight (MW) | 414.46 | |
| SMILES | C1COCCN1C2=CC=C(C=C2)NC3=NC=CC(=N3)C4=CC=C(C=C4)C(=O)NCC#N | |
| InChIKey | ZVHNDZWQTBEVRY-UHFFFAOYSA-N |
Momelotinib (CYT387) is an ATP-competitive inhibitor targeting JAK1 (IC50 = 11 nM) and JAK2 (IC50 = 18 nM), displaying approximately 10-fold selectivity over JAK3. By inhibiting the JAK/STAT signaling pathway, it suppresses downstream STAT3 and STAT5 phosphorylation. Consequently, momelotinib suppresses cell growth, blocks cellular proliferation, and induces apoptosis and autophagy in myeloproliferative neoplasm cells. [1]
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
83 mg/mL
(200.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
83 mg/mL
(200.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
83 mg/mL
(200.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
83 mg/mL
(200.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
74 mg/mL
(178.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Momelotinib (CYT387) Mechanism of Action: JAK2 Inhibition in Hematopoietic Stem Cell Research
- Momelotinib (CYT387) Clinical Trials
- Momelotinib (CYT387): Selectivity & Specificity
- Momelotinib (CYT387) Working Concentration | Cell Culture | Treatment
- Momelotinib (CYT387) Solubility in DMSO
- Momelotinib (CYT387) Storage
- Momelotinib (CYT387) Stability
- Momelotinib (CYT387) Combination Database
- Momelotinib (CYT387) Molecular Weight
- Momelotinib (CYT387) SMILES
- Momelotinib (CYT387) Chemical Structure (2D and 3D)
- Momelotinib (CYT387) IC50 for Cell-based and Cell-free Assays
- Momelotinib (CYT387) MedChemExpress (HY-10961)? Try a better option.
- Momelotinib (CYT387) Cayman (16246)? Try a better option.
- Momelotinib (CYT387) Sigma (AMBH303C4FDE)? Try a better option.
- Momelotinib (CYT387) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.