CAS No. 2320462-65-3
Batch:
Purity:99.72
Chemical Structure
Check the
CompK
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-[[4-[[(1S)-2-hydroxy-1-phenylethyl]amino]-5-(1,3,4-oxadiazol-2-yl)pyrimidin-2-yl]amino]-3,3-dimethyl-2-benzofuran-1-one | |
|---|---|---|
| CAS Number | 2320462-65-3 | |
| Molecular Formula |
C24H22N6O4 |
|
| Molecular Weight (MW) | 458.47 | |
| InChIKey | RVSSNRBUPQUIEG-LJQANCHMSA-N |
CompK (compound K) is a potent and selective small molecule inhibitor of hematopoietic progenitor kinase 1 (HPK1 or MAP4K1). By inhibiting HPK1 within the T-cell receptor signaling pathway, CompK markedly enhances human T-cell immune responses under immunosuppressive conditions relevant to the tumor microenvironment, increasing T-cell receptor avidity to recognize tumor-associated antigens and boosting the cytolytic activity of CD8+ T cells. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
92 mg/mL
(200.66 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.