CAS No. 5786-21-0
| IUPAC Name | 3-chloro-6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine | |
|---|---|---|
| CAS Number | 5786-21-0 | |
| Molecular Formula |
C18H19ClN4 |
|
| Molecular Weight (MW) | 326.82 | |
| SMILES | CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42 | |
| InChIKey | QZUDBNBUXVUHMW-UHFFFAOYSA-N |
Clozapine is an atypical antipsychotic agent that acts as a potent 5-HT1C receptor antagonist to inhibit serotonin-stimulated phosphoinositide hydrolysis. It exhibits a distinct binding profile across serotonergic and dopaminergic receptors compared to typical antipsychotics. By modulating serotonin and dopamine receptor-mediated signaling pathways, clozapine regulates downstream intracellular signaling and alters dopamine-mediated cellular phenotypes. [1][2]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
65 mg/mL
(198.88 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 65 mg/mL |
| Water | Insoluble |
| DMSO |
65 mg/mL
(198.88 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
| DMSO |
65 mg/mL
(198.88 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 32 mg/mL |
| Water | Insoluble |
| DMSO |
65 mg/mL
(198.88 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 22 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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