CAS No. 7081-44-9
| CAS Number | 7081-44-9 | |
|---|---|---|
| Molecular Formula |
C19H19ClN3NaO6S |
|
| Molecular Weight (MW) | 475.88 | |
| SMILES | CC1=C(C(=NO1)C2=CC=CC=C2Cl)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)[O-].O.[Na+] |
Cloxacillin sodium is a semi-synthetic, penicillinase-resistant beta-lactam antibiotic that targets penicillin-binding proteins (PBPs). By binding to PBPs, it inhibits the cross-linking transpeptidation step in bacterial cell wall peptidoglycan biosynthesis. This disruption weakens the bacterial cell wall, compromising structural integrity and leading to cell lysis and bactericidal activity against susceptible microorganisms during active cell multiplication. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
55 mg/mL
(115.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 55 mg/mL |
| Ethanol | 25 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
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