CAS No. 17321-77-6

Batch: Purity:99.75
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Clomipramine HCl Chemical Structure
Chemical Structure
Check the Clomipramine HCl product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine;hydrochloride
CAS Number 17321-77-6
Molecular Formula

C19H23ClN2.HCl
Molecular Weight (MW) 351.31
SMILES CN(C)CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl.Cl
InChIKey WIMWMKZEIBHDTH-UHFFFAOYSA-N

Ordering Information

Biological Activity

Clomipramine HCl is a tricyclic antidepressant that acts as a potent serotonin transporter (SERT) inhibitor (Ki = and also blocks dopamine transporter (DAT, Ki = 3 nM) and norepinephrine transporter (NET, Ki =. It additionally acts as an antagonist at histamine H1 (Ki =, 5-HT2A (Ki =, and muscarinic acetylcholine receptors (Ki = 37 nM). By modulating monoamine neurotransmission, it inhibits 5-HT reuptake (IC50 = and is widely used in research on depression and anxiety. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 70 mg/mL (199.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 70 mg/mL
Ethanol 70 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.