CAS No. 637-07-0
| CAS Number | 637-07-0 | |
|---|---|---|
| Molecular Formula |
C12H15ClO3 |
|
| Molecular Weight (MW) | 242.7 | |
| SMILES | CCOC(=O)C(C)(C)OC1=CC=C(C=C1)Cl |
Clofibrate is a fibric acid derivative and peroxisome proliferator-activated receptor alpha (PPARα) agonist used for managing hyperlipoproteinemia and hypertriglyceridemia. It enhances the activity of extrahepatic lipoprotein lipase, promoting triglyceride lipolysis and the degradation of chylomicrons. Additionally, clofibrate suppresses the synthesis and accelerates the clearance of apolipoprotein B, leading to reduced VLDL levels and elevated HDL concentrations. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
7 mg/mL
(28.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
| DMSO |
7 mg/mL
(28.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
| DMSO |
7 mg/mL
(28.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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