CAS No. 480-40-0
| IUPAC Name | 5,7-dihydroxy-2-phenylchromen-4-one | |
|---|---|---|
| CAS Number | 480-40-0 | |
| Molecular Formula |
C15H10O4 |
|
| Molecular Weight (MW) | 254.24 | |
| SMILES | C1=CC=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)O)O | |
| InChIKey | RTIXKCRFFJGDFG-UHFFFAOYSA-N |
Chrysin is a naturally occurring flavone that acts as an inhibitor of cyclooxygenase-2 (COX-2) expression and modulates IL-6 and NF-kB signaling pathways. By attenuating NF-kB activation and suppressing proinflammatory cytokine secretion, Chrysin demonstrates potent anti-inflammatory and antioxidant activities in cell-based assays. These cellular alterations reduce downstream inflammatory responses and mediate protective phenotypes across various in vitro models of inflammation.
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
51 mg/mL
(200.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
51 mg/mL
(200.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
51 mg/mL
(200.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
51 mg/mL
(200.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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