CAS No. 113-59-7
Batch:
Purity:99.42
Chemical Structure
Check the
Chlorprothixene
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (3Z)-3-(2-chlorothioxanthen-9-ylidene)-N,N-dimethylpropan-1-amine | |
|---|---|---|
| CAS Number | 113-59-7 | |
| Molecular Formula |
C18H18ClNS |
|
| Molecular Weight (MW) | 315.86 | |
| SMILES | CN(C)CCC=C1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl | |
| InChIKey | WSPOMRSOLSGNFJ-AUWJEWJLSA-N |
Biological Activity
Chlorprothixene is a thioxanthene typical antipsychotic that potently targets D2 receptor (Ki 2.96 nM), D3 receptor (Ki 4.56 nM), D1 receptor (Ki 18 nM), D5 receptor (Ki 9 nM), H1 receptor (Ki 3.75 nM), 5-HT6 receptor (Ki 3 nM), 5-HT7 receptor (Ki 5.6 nM), and 5-HT2 receptor (Ki 9.4 nM). By antagonizing central dopamine and serotonin receptors, it blocks G-protein-coupled receptor signaling pathways, leading to suppressed dopaminergic transmission and sedative phenotypes. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Ethanol | 28 mg/mL |
| DMSO |
6 mg/mL
(18.99 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.