CAS No. 288383-20-0
Batch:
Purity:99.64
Chemical Structure
Check the
Cediranib (AZD2171)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline | |
|---|---|---|
| CAS Number | 288383-20-0 | |
| Molecular Formula |
C25H27FN4O3 |
|
| Molecular Weight (MW) | 450.51 | |
| SMILES | CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCC5 | |
| InChIKey | XXJWYDDUDKYVKI-UHFFFAOYSA-N |
Cediranib (AZD2171) is a potent vascular endothelial growth factor receptor inhibitor targeting KDR (IC50 1 nM), Flt-1, and Flt-4. In endothelial cells, it suppresses VEGF-stimulated KDR phosphorylation (IC50 0. and cell proliferation (IC50 0.4 nM). Blockade of these receptor tyrosine kinase pathways leads to downstream inhibition of angiogenesis and tumor vascular permeability. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
90 mg/mL
(199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 6 mg/mL |
| Water | Insoluble |
| DMSO |
90 mg/mL
(199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
90 mg/mL
(199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
| DMSO |
90 mg/mL
(199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
90 mg/mL
(199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Cediranib (AZD2171) Clinical Trials
- Cediranib (AZD2171) Solubility in DMSO
- Cediranib (AZD2171) Stock Solution
- Cediranib (AZD2171) Storage
- Cediranib (AZD2171) Stability
- Cediranib (AZD2171) Molecular Weight
- Cediranib (AZD2171) SMILES
- Cediranib (AZD2171) Chemical Structure (2D and 3D)
- Cediranib (AZD2171) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.