CAS No. 298-46-4

Batch: Purity:99.93
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Carbamazepine Chemical Structure
Chemical Structure
Check the Carbamazepine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name benzo[b][1]benzazepine-11-carboxamide
CAS Number 298-46-4
Molecular Formula

C15H12N2O
Molecular Weight (MW) 236.27
SMILES C1=CC=C2C(=C1)C=CC3=CC=CC=C3N2C(=O)N
InChIKey FFGPTBGBLSHEPO-UHFFFAOYSA-N

Ordering Information

Biological Activity

Carbamazepine is a voltage-gated sodium channel blocker that targets neuronal sodium channels. It binds to and stabilizes the inactivated state of voltage-gated sodium channels, reducing the fraction of channels available for activation during membrane depolarization. This stabilization inhibits frequency-dependent repetitive firing of action potentials, thereby suppressing neuronal excitability and modulating downstream neurotransmitter release. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 47 mg/mL (198.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 47 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.