CAS No. 917111-44-5

Batch: Purity:99.91
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Lexibulin (CYT997) Chemical Structure
Chemical Structure
Check the Lexibulin (CYT997) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-ethyl-3-[2-methoxy-4-[5-methyl-4-[[(1S)-1-pyridin-3-ylbutyl]amino]pyrimidin-2-yl]phenyl]urea
CAS Number 917111-44-5
Molecular Formula

C24H30N6O2
Molecular Weight (MW) 434.53
SMILES CCCC(C1=CN=CC=C1)NC2=NC(=NC=C2C)C3=CC(=C(C=C3)NC(=O)NCC)OC
InChIKey MTJHLONVHHPNSI-IBGZPJMESA-N

Ordering Information

Biological Activity

Lexibulin (CYT997) is a potent microtubule polymerization inhibitor that suppresses tubulin polymerization with an IC50 of ~3 μmol/L and exhibits antiproliferative activity across various cancer cell lines with IC50 values ranging from 1 tool/L. Treatment with Lexibulin induces cell cycle arrest at the G2-M phase, triggers caspase-3 activation and PARP cleavage, and disrupts endothelial cell monolayers to demonstrate significant vascular disrupting effects. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 86 mg/mL (197.91 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 20 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.