CAS No. 1012054-59-9
| IUPAC Name | 7-[4-(3-ethynylanilino)-7-methoxyquinazolin-6-yl]oxy-N-hydroxyheptanamide | |
|---|---|---|
| CAS Number | 1012054-59-9 | |
| Molecular Formula |
C24H26N4O4 |
|
| Molecular Weight (MW) | 434.49 | |
| SMILES | COC1=C(C=C2C(=C1)N=CN=C2NC3=CC=CC(=C3)C#C)OCCCCCCC(=O)NO | |
| InChIKey | PLIVFNIUGLLCEK-UHFFFAOYSA-N |
CUDC-101 is a potent multi-targeted inhibitor of HDAC, EGFR, and HER2. It effectively blocks class I and II HDACs and suppresses receptor tyrosine kinase autophosphorylation, leading to downstream inhibition of AKT and MAPK signaling pathways. Consequently, CUDC-101 exhibits robust antiproliferative activity across diverse cancer cell lines and induces marked tumor regression in xenograft models of non-small cell lung, pancreatic, and breast cancers. [1][2]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
43 mg/mL
(98.96 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
40 mg/mL
(92.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
20 mg/mL
(46.03 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
44 mg/mL
(101.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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