CAS No. 1397219-81-6 

Batch: Purity:99.79
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BS-181 HCl Chemical Structure
Chemical Structure
Check the BS-181 HCl product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-N-(6-aminohexyl)-7-N-benzyl-3-propan-2-ylpyrazolo[1,5-a]pyrimidine-5,7-diamine;hydrochloride
CAS Number 1397219-81-6 
Molecular Formula

C22H32N6.HCl
Molecular Weight (MW) 416.99
SMILES Cl.CC(C)C1=C2N=C(NCCCCCCN)C=C(NCC3=CC=CC=C3)[N]2N=C1
InChIKey NVIJWMOQODWNFN-UHFFFAOYSA-N

Biological Activity

BS-181 HCl is a potent and selective cyclin-dependent kinase 7 (CDK7) inhibitor with an IC50 of 21 nM, exhibiting over 35-fold selectivity over CDK2 (IC50 880 nM). By suppressing CDK7 activity, it inhibits the phosphorylation of downstream targets such as RNA polymerase II, leading to cell cycle arrest at the G1 phase and induction of apoptosis. Consequently, BS-181 HCl reduces cancer cell proliferation and exhibits robust antitumor activity in animal models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 83 mg/mL (199.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 83 mg/mL
Ethanol 22 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Ali S, et al. Cancer Res. 2009;69(15):6208-15.

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Note: Technical data last updated: Sep 1, 2026.