CAS No. 1174046-72-0
| IUPAC Name | N-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-5-(4-fluorophenyl)-4-oxo-1H-pyridine-3-carboxamide | |
|---|---|---|
| CAS Number | 1174046-72-0 | |
| Molecular Formula |
C23H15ClF2N4O3 |
|
| Molecular Weight (MW) | 468.84 | |
| SMILES | C1=CC(=CC=C1C2=CNC=C(C2=O)C(=O)NC3=CC(=C(C=C3)OC4=C(C(=NC=C4)N)Cl)F)F | |
| InChIKey | PDYXPCKITKHFOZ-UHFFFAOYSA-N |
BMS-794833 is an ATP-competitive kinase inhibitor of Met (IC50 1.7 nM) and VEGFR2 (IC50 15 nM), while also inhibiting Ron, Axl, and Flt3 (IC50 <3 nM). By suppressing receptor tyrosine kinase signaling, it inhibits the proliferation of constitutively Met-activated GTL-16 gastric carcinoma cells and HGF-stimulated U87 glioblastoma cells. In vivo, oral administration of BMS-794833 produces dose-dependent tumor growth inhibition in both Met-dependent and Met-insensitive xenograft models.
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
94 mg/mL
(200.49 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
94 mg/mL
(200.49 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
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- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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