CAS No. 1146699-66-2

Batch: Purity:99.63
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Avagacestat (BMS-708163) Chemical Structure
Chemical Structure
Check the Avagacestat (BMS-708163) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2R)-2-[(4-chlorophenyl)sulfonyl-[[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide
CAS Number 1146699-66-2
Molecular Formula

C20H17ClF4N4O4S
Molecular Weight (MW) 520.88
SMILES C1=CC(=CC=C1S(=O)(=O)N(CC2=C(C=C(C=C2)C3=NOC=N3)F)C(CCC(F)(F)F)C(=O)N)Cl
InChIKey XEAOPVUAMONVLA-QGZVFWFLSA-N

Ordering Information

Biological Activity

Avagacestat (BMS-708163) is a potent, orally bioavailable γ-secretase inhibitor that blocks amyloid precursor protein processing to suppress Aβ40 (IC50 = and Aβ42 (IC50 = production, displaying a 193-fold selectivity over Notch (IC50 =. By selectively targeting γ-secretase cleavage, it decreases extracellular β-amyloid peptide accumulation while sparing Notch-dependent cell signaling pathways. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 104 mg/mL (199.66 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.