CAS No. 1094614-84-2

Batch: Purity:99.01
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(E/Z)-BIX02188 Chemical Structure
Chemical Structure
Check the (E/Z)-BIX02188 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-[N-[3-[(dimethylamino)methyl]phenyl]-C-phenylcarbonimidoyl]-2-hydroxy-1H-indole-6-carboxamide
CAS Number 1094614-84-2
Molecular Formula

C25H24N4O2
Molecular Weight (MW) 412.48
SMILES CN(C)CC1=CC(=CC=C1)N=C(C2=CC=CC=C2)C3=C(NC4=C3C=CC(=C4)C(=O)N)O
InChIKey WGPXKFOFEXJMBD-UHFFFAOYSA-N

Biological Activity

(E/Z)-BIX02188 is a potent and selective kinase inhibitor targeting MEK5 (IC50 of and ERK5 catalytic activity (IC50 of, while showing minimal activity against closely related kinases MEK1, MEK2, ERK2, and JNK2. By selectively suppressing the MEK5/ERK5 signaling axis, it blocks downstream transcription factor activation and inhibits gene expression associated with cell proliferation, vascular function, and neuronal responses. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 43 mg/mL (104.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 3 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Tatake RJ, et al. Biochem Biophys Res Commun. 2008;377(1):120-5.

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Note: Technical data last updated: Sep 1, 2026.