CAS No. 211914-51-1
| IUPAC Name | 3-[[2-[(4-carbamimidoylanilino)methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoic acid | |
|---|---|---|
| CAS Number | 211914-51-1 | |
| Molecular Formula |
C25H25N7O3 |
|
| Molecular Weight (MW) | 471.51 | |
| SMILES | CN1C2=C(C=C(C=C2)C(=O)N(CCC(=O)O)C3=CC=CC=N3)N=C1CNC4=CC=C(C=C4)C(=N)N | |
| InChIKey | YBSJFWOBGCMAKL-UHFFFAOYSA-N |
Dabigatran is a reversible, competitive, direct thrombin inhibitor that selectively blocks central coagulation processes. By specifically binding to and inhibiting active thrombin, it prevents the enzymatic cleavage of fibrinogen into fibrin monomers within the blood coagulation cascade. This targeted inhibition effectively suppresses thrombin-mediated activation of platelets and downstream clot formation, resulting in robust antithrombotic activity and reduced thrombus development. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
0.5 mg/mL
(1.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | 0.01 mg/mL |
| Water | Insoluble |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| 5%TFA | 6.06 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| 5%TFA | 6.09 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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