CAS No. 5508-58-7

Batch: Purity:99.89
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Andrographolide Chemical Structure
Chemical Structure
Check the Andrographolide product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]-4-hydroxyoxolan-2-one
CAS Number 5508-58-7
Molecular Formula

C20H30O5
Molecular Weight (MW) 350.45
SMILES CC12CCC(C(C1CCC(=C)C2CC=C3C(COC3=O)O)(C)CO)O
InChIKey BOJKULTULYSRAS-OTESTREVSA-N

Ordering Information

Biological Activity

Andrographolide is a natural labdane diterpenoid that functions as a potent anti-inflammatory and antitumor agent. It covalently modifies the p50 subunit of NF-kB to inhibit NF-kB transcriptional activation and suppress downstream inflammatory cytokine production. Furthermore, Andrographolide inhibits PI3K/AKT signaling cascade, resulting in cell cycle arrest and apoptosis in various human cancer cell lines. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 70 mg/mL (199.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.