CAS No. 71675-85-9

Batch: Purity:99.93
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Amisulpride Chemical Structure
Chemical Structure
Check the Amisulpride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-amino-N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxybenzamide
CAS Number 71675-85-9
Molecular Formula

C17H27N3O4S
Molecular Weight (MW) 369.48
SMILES CCN1CCCC1CNC(=O)C2=CC(=C(C=C2OC)N)S(=O)(=O)CC
InChIKey NTJOBXMMWNYJFB-UHFFFAOYSA-N

Biological Activity

Amisulpride is an atypical antipsychotic compound that acts as a selective antagonist of dopamine D2 receptor (Kd 2.8 nM) and dopamine D3 receptor (Kd 3.2 nM). By blocking presynaptic and postsynaptic dopamine receptors, it modulates dopaminergic signaling pathways in the central nervous system. This inhibition suppresses dopamine-mediated cellular signaling and reduces hyperdopaminergic cellular responses. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 73 mg/mL (197.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 73 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Schoemaker H, et al. J Pharmacol Exp Ther. 1997;280(1):83-97.

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Note: Technical data last updated: Sep 1, 2026.