CAS No. 317-34-0
| IUPAC Name | bis(1,3-dimethyl-7H-purine-2,6-dione);ethane-1,2-diamine | |
|---|---|---|
| CAS Number | 317-34-0 | |
| Molecular Formula |
C16H24N10O4 |
|
| Molecular Weight (MW) | 420.43 | |
| SMILES | CN1C2=C(C(=O)N(C1=O)C)NC=N2.CN1C2=C(C(=O)N(C1=O)C)NC=N2.C(CN)N | |
| InChIKey | FQPFAHBPWDRTLU-UHFFFAOYSA-N |
Aminophylline is a competitive, nonselective phosphodiesterase (PDE) inhibitor and a nonselective adenosine receptor antagonist. By inhibiting PDE enzymes, it prevents the degradation of cyclic adenosine monophosphate (cAMP), leading to increased intracellular cAMP levels. This elevation promotes airway smooth muscle relaxation, inhibits inflammatory cell activation, and reduces bronchial hyperresponsiveness, serving as an effective bronchodilator in respiratory pathway research.
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| Water | 81 mg/mL |
| DMSO |
53 mg/mL
(126.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 1 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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