CAS No. 645-05-6

Batch: Purity:99.74
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Altretamine Chemical Structure
Chemical Structure
Check the Altretamine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 645-05-6
Molecular Formula

C9H18N6
Molecular Weight (MW) 210.28
SMILES CN(C)C1=NC(=NC(=N1)N(C)C)N(C)C

Biological Activity

Altretamine is an anti-neoplastic alkylating agent that acts as a synthetic antineoplastic compound. It undergoes metabolic activation to form reactive intermediate species that damage nucleic acids and impair DNA synthesis. This DNA modification inhibits tumor cell proliferation and disrupts essential cellular pathways, ultimately leading to cytotoxic effects and cell death in cancer cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Ethanol 33 mg/mL
DMSO 15 mg/mL (71.33 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Markham A, et al. Drugs. 1995;50(2):317-33.

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Note: Technical data last updated: Sep 1, 2026.