CAS No. 531-75-9

Batch: Purity:99.93
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Esculin Chemical Structure
Chemical Structure
Check the Esculin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 531-75-9
Molecular Formula

C15H16O9

Molecular Weight (MW) 340.28
SMILES C1=CC(=O)OC2=CC(=C(C=C21)OC3C(C(C(C(O3)CO)O)O)O)O

Biological Activity

Esculin is a naturally occurring coumarin glucoside that exhibits potent anti-inflammatory and antioxidant activities. It suppresses lipopolysaccharide-induced production of pro-inflammatory cytokines, such as TNF-α and IL-6, by attenuating the activation of NF-κB and MAPK signaling pathways. Additionally, esculin mitigates oxidative stress by scavenging intracellular reactive oxygen species and enhancing cellular antioxidant enzyme defenses.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 68 mg/mL (199.83 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.